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Basal and induced E...
Basal and induced EROD activity in the chorioallantoic membrane during chicken embryo development
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- Annas, Anita (author)
- Uppsala universitet,Avdelningen för toxikologi
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- Granberg, Lena (author)
- Uppsala universitet,Ekotoxikologi
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- Strandberg, William (author)
- Uppsala universitet,Ekotoxikologi
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- Brandt, Ingvar (author)
- Uppsala universitet,Ekotoxikologi
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- Brittebo, Eva B (author)
- Uppsala universitet,Avdelningen för toxikologi
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- Brunström, Björn (author)
- Uppsala universitet,Ekotoxikologi
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(creator_code:org_t)
- 1999
- 1999
- English.
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In: Environmental Toxicology and Pharmacology. - 1382-6689 .- 1872-7077. ; 8:1, s. 49-52
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The chorioallantoic membrane (CAM) is a highly vascularized tissue that takes part in the respiratory exchange of gases through the eggshell. Although the CAM may be exposed to environmental contaminants, its response to pollutants has not been studied. We examined the cytochrome P4501A (CYP1A)-catalyzed deethylation of 7-ethoxyresorufin (EROD) in the CAM during chicken embryo development. EROD was constitutively present and was inducible by the aryl hydrocarbon (Ah) receptor agonist 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126). Our results suggest the CAM as a first line of defence of the avian embryo against toxic compounds, but also as a target for CYP1A-activated chemicals.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- CAM
- chorioallantoic membrane
- CYP1A
- EROD
- PCB 126
- PHARMACY
- FARMACI
Publication and Content Type
- vet (subject category)
- art (subject category)
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