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- Batista, N (author)
Phase II study of capecitabine in combination with paclitaxel in patients with anthracycline-pretreated advanced/metastatic breast cancer.
- Article/chapterEnglish2004
Publisher, publication year, extent ...
- 2004
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-81295
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-81295URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- The addition of oral capecitabine to docetaxel improves response rate, time to progression (TTP) and overall survival in anthracycline-pretreated metastatic breast cancer (MBC). This phase II study evaluates the efficacy and safety of a 21-day cycle of oral capecitabine (1000 mg m(-2) twice daily, days 1-14) plus i.v. paclitaxel (175 mg m(-2), day 1) in anthracycline-pretreated advanced/MBC. In all, 73 patients were enrolled at 13 Swedish and Spanish centres. The objective response rate was 52% (95% confidence interval (CI): 40-63%) in the intent-to-treat population, including complete responses in 11%. Disease was stabilised in a further 29%. The median time to disease progression (TTP) was 8.1 months and the median overall survival was 16.5 months. The combination was generally well tolerated with a predictable safety profile. The most common treatment-related nonhaematological adverse events were hand-foot syndrome (42%), alopecia (30%) and diarrhoea (26%). The only treatment-related Grade 3/4 adverse events occurring in >5% of patients were alopecia (22%) and hand-foot syndrome (11%). Grade 3/4 neutropenia and lymphocytopenia were reported in 12 and 14% of patients, respectively. Capecitabine plus paclitaxel is highly active with a favourable safety profile in anthracycline-pretreated MBC.
Subject headings and genre
- Adolescent
- Adult
- Aged
- Anthracyclines/therapeutic use
- Antineoplastic Agents/therapeutic use
- Antineoplastic Combined Chemotherapy Protocols/adverse effects/*therapeutic use
- Breast Neoplasms/*drug therapy/mortality
- Deoxycytidine/administration & dosage/adverse effects/*analogs & derivatives
- Disease Progression
- Female
- Humans
- Maximum Tolerated Dose
- Middle Aged
- Paclitaxel/administration & dosage/adverse effects
- Survival Rate
- Treatment Outcome
Added entries (persons, corporate bodies, meetings, titles ...)
- Perez-Manga, G (author)
- Constenla, M (author)
- Ruiz, A (author)
- Carabantes, F (author)
- Castellanos, J (author)
- Gonzalez Baron, M (author)
- Villman, K (author)
- Söderberg, M (author)
- Ahlgren, JUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Centrum för klinisk forskning, Gävleborg (author)
- Casinello, J (author)
- Regueiro, P (author)
- Murias, A (author)
- Uppsala universitetInstitutionen för onkologi, radiologi och klinisk immunologi (creator_code:org_t)
Related titles
- In:Br J Cancer90:9, s. 1740-60007-0920
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