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Nitric oxide exposu...
Nitric oxide exposure diverts neural stem cell fate from neurogenesis towards astrogliogenesis
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- Covacu, Ruxandra (author)
- Karolinska Institutet
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- Danilov, Alexandre (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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Rasmussen, Bo Sonnich (author)
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- Hallén, Katarina (author)
- Karolinska Institutet
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Moe, Morten C. (author)
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- Lobell, Anna (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Lobell / Kämpe
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Johansson, Clas B. (author)
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Svensson, Mikael A. (author)
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- Olsson, Tomas (author)
- Karolinska Institutet
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- Brundin, Lou (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2009-01-02
- 2006
- English.
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In: Stem Cells. - : Oxford University Press (OUP). - 1066-5099 .- 1549-4918. ; 178, s. 268-268
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Abstract
Subject headings
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- Regeneration of cells in the central nervous system is a process that might be affected during neurological disease and trauma. Because nitric oxide (NO) and its derivatives are powerful mediators in the inflammatory cascade, we have investigated the effects of pathophysiological concentrations of NO on neurogenesis, gliogenesis, and the expression of proneural genes in primary adult neural stem cell cultures. After exposure to NO, neurogenesis was downregulated, and this corresponded to decreased expression of the proneural gene neurogenin-2 and beta-III-tubulin. The decreased ability to generate neurons was also found to be transmitted to the progeny of the cells. NO exposure was instead beneficial for astroglial differentiation, which was confirmed by increased activation of the Janus tyrosine kinase/signal transducer and activator of transcription transduction pathway. Our findings reveal a new role for NO during neuroinflammatory conditions, whereby its proastroglial fate-determining effect on neural stem cells might directly influence the neuroregenerative process.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Autoimmune disease
- Nitric oxide
- Neural stem cell
- Neural differentiation
- Glial differentiation
- MEDICINE
- MEDICIN
- Autoimmune disease
- Nitric oxide
- Neural stem cell
- Neural differentiation
- Glial differentiation
Publication and Content Type
- vet (subject category)
- art (subject category)
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Stem Cells
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- By the author/editor
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Covacu, Ruxandra
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Danilov, Alexand ...
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Rasmussen, Bo So ...
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Hallén, Katarina
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Moe, Morten C.
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Lobell, Anna
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show more...
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Johansson, Clas ...
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Svensson, Mikael ...
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Olsson, Tomas
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Brundin, Lou
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Stem Cells
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JOURNAL OF NEURO ...
- By the university
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Uppsala University
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Lund University
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Karolinska Institutet