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  • Covacu, RuxandraKarolinska Institutet (author)

Nitric oxide exposure diverts neural stem cell fate from neurogenesis towards astrogliogenesis

  • Article/chapterEnglish2006

Publisher, publication year, extent ...

  • 2009-01-02
  • Oxford University Press (OUP),2006
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-82125
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-82125URI
  • https://doi.org/10.1634/stemcells.2005-0640DOI
  • https://lup.lub.lu.se/record/1137319URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:1943986URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:1595593URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:vet swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Regeneration of cells in the central nervous system is a process that might be affected during neurological disease and trauma. Because nitric oxide (NO) and its derivatives are powerful mediators in the inflammatory cascade, we have investigated the effects of pathophysiological concentrations of NO on neurogenesis, gliogenesis, and the expression of proneural genes in primary adult neural stem cell cultures. After exposure to NO, neurogenesis was downregulated, and this corresponded to decreased expression of the proneural gene neurogenin-2 and beta-III-tubulin. The decreased ability to generate neurons was also found to be transmitted to the progeny of the cells. NO exposure was instead beneficial for astroglial differentiation, which was confirmed by increased activation of the Janus tyrosine kinase/signal transducer and activator of transcription transduction pathway. Our findings reveal a new role for NO during neuroinflammatory conditions, whereby its proastroglial fate-determining effect on neural stem cells might directly influence the neuroregenerative process.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Danilov, AlexandreLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-ada (author)
  • Rasmussen, Bo Sonnich (author)
  • Hallén, KatarinaKarolinska Institutet (author)
  • Moe, Morten C. (author)
  • Lobell, AnnaUppsala universitet,Institutionen för medicinska vetenskaper,Lobell / Kämpe(Swepub:uu)anlob030 (author)
  • Johansson, Clas B. (author)
  • Svensson, Mikael A. (author)
  • Olsson, TomasKarolinska Institutet (author)
  • Brundin, LouKarolinska Institutet (author)
  • Karolinska InstitutetNeurologi, Lund (creator_code:org_t)

Related titles

  • In:Stem Cells: Oxford University Press (OUP)178, s. 268-2681066-50991549-4918
  • In:JOURNAL OF NEUROIMMUNOLOGY: Oxford University Press (OUP)178, s. 268-2680165-5728

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