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Otomicroscopic find...
Otomicroscopic findings and systemic interleukin-6 levels in relation to etiologic agent during experimental acute otitis media
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Foglé-Ansson, Margaretha (author)
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- White, Peter (author)
- Lund University,Lunds universitet,Öron-, näs- och halssjukdomar, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Otorhinolaryngology (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Hermansson, Ann (author)
- Lund University,Lunds universitet,Öron-, näs- och halssjukdomar, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Otorhinolaryngology (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Melhus, Åsa (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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(creator_code:org_t)
- Wiley, 2006
- 2006
- English.
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In: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). - : Wiley. - 0903-4641 .- 1600-0463. ; 114:4, s. 285-291
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Abstract
Subject headings
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- The aim of the present study was to explore whether it was possible to differentiate the clinical course and the otomicroscopic appearance of acute otitis media (AOM) caused by common otitis pathogens in an animal model. Systemic interleukin (IL)-6 levels as early markers for bacterial AOM were also studied. Four groups of rats were inoculated with either Streptococcus pneumoniae, Streptococcus pyogenes, non-typeable Haemophilus influenzae or Moraxella catarrhalis. The animals were monitored by otomicroscopy, photos of the tympanic membrane, cultures and IL-6 detection in serum the following 4 days. The gram-positive S. pneumoniae and S. pyogenes induced severe AOM with opaque effusion behind the tympanic membrane, pronounced dilation of the vessels and spontaneous perforations. The gram-negative H. influenzae and M. catarrhalis induced a less severe infection with cloudy, sometimes foamy effusion, and no spontaneous perforations. With the otomicroscopic findings it was possible to distinguish between infections induced by gram-positive bacteria and gram-negative bacteria. Detection of interleukin-6 in serum appeared to be of limited use for all infections except the pneumococcal AOM, but this needs to be further investigated.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
Keyword
- Acute Disease
- Animals
- Bacterial Infections/*microbiology/*pathology
- Disease Models; Animal
- Haemophilus influenzae/immunology/isolation & purification
- Interleukin-6/*blood
- Male
- Moraxella (Branhamella) catarrhalis/immunology/isolation & purification
- Otitis Media/*microbiology/*pathology
- Rats
- Rats; Sprague-Dawley
- Research Support; Non-U.S. Gov't
- Streptococcus pneumoniae/immunology/isolation & purification
- Streptococcus pyogenes/immunology/isolation & purification
- Tympanic Membrane/microbiology/*pathology
- MEDICINE
- MEDICIN
- otomicroscopy
- IL-6
- diagnosis
- acute otitis media
- animal model
Publication and Content Type
- ref (subject category)
- art (subject category)
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