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Toxic epidermal nec...
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Arvidson, JohanUppsala universitet,Institutionen för kvinnors och barns hälsa,Barnonkologisk forskning/Lönnerholm
(author)
Toxic epidermal necrolysis and hemolytic uremic syndrome after allogeneic stem-cell transplantation
- Article/chapterEnglish2007
Publisher, publication year, extent ...
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2007-06-16
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Wiley,2007
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-85160
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-85160URI
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https://doi.org/10.1111/j.1399-3046.2007.00743.xDOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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TEN and HUS are challenging complications with excessive mortality after HSCT. We report the development of these two conditions in combination in a nine-yr-old boy after HSCT from an unrelated donor. TEN with skin detachment of more than 90% of body surface area developed after initial treatment for GvHD. Within a few days of admission to the burns unit, the patient developed severe hemolysis, hypertension, thrombocytopenia, and acute renal failure consistent with HUS, apparently caused by CSA. The management included intensive care in a burns unit, accelerated drug removal using plasmapheresis, and a dedicated multi-disciplinary team approach to balance immunosuppression and infections management in a situation with extensive skin detachment. The patient survived and recovered renal function but requires continued treatment for severe GvHD. Suspecting and identifying causative drugs together with meticulous supportive care in the burns unit is essential in the management of these patients and long-term survival is possible.
Subject headings and genre
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children
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allogeneic stem cell transplantation
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hemolytic uremic syndrome
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toxic epidermal necrolysis
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cyclosporine A
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plasmapheresis
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MEDICINE
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MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
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Kildal, MortenUppsala universitet,Institutionen för kirurgiska vetenskaper(Swepub:uu)mortkild
(author)
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Linde, TorbjörnUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)torblind
(author)
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Gedeborg, RolfUppsala universitet,Anestesiologi och intensivvård(Swepub:uu)rolfgede
(author)
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Uppsala universitetInstitutionen för kvinnors och barns hälsa
(creator_code:org_t)
Related titles
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In:Pediatric Transplantation: Wiley11:6, s. 689-6931397-31421399-3046
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