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Effects of pre-and ...
Effects of pre-and postmenopausal use of exogenous hormones on receptor content in normal human breast tissue: A randomized study
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- Hallberg, Gunilla (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Gynekologisk endokrionologi/Naessén
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- Persson, Ingemar (author)
- Karolinska Institute, Stockholm, Sweden
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- Naessén, Tord (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Gynekologisk endokrinologi/Naessén
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- Magnusson, Cecilia (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2009-07-07
- 2008
- English.
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In: Gynecological Endocrinology. - : Informa UK Limited. - 0951-3590 .- 1473-0766. ; 24:8, s. 475-480
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Objective. To examine the effects of exposure to endogenous and exogenous hormones on estrogen receptor- (ER) and progesterone receptor (PR) levels in normal human breast tissue. Methods. In a randomized study of women scheduled for mammary reduction plasty (n = 81), ER and PR content in breast parenchyma was analyzed in premenopausal (n = 49) and postmenopausal (n = 16) women. Premenopausal women were randomized to surgery in the follicular or luteal phase of the menstrual cycle or after oral contraceptive treatment for 2 months. Postmenopausal women were randomized to sequential or estrogen-only therapy for 2 months prior to surgery. Results. ER content was higher in parous than in nulliparous (p = 0.009) premenopausal women and displayed a positive association with age (rs = 0.51, p = 0.0002). Compared with premenopausal women in the follicular phase, postmenopausal women had higher ER content (p = 0.040) whereas premenopausal women on oral contraception had lower ER (p = 0.048) and PR (p = 0.007) content. Smokers had lower PR content than non-smokers (p = 0.02). Conclusion. In the present study ER content was higher in parous than in non-parous women and associated with premenopausal age. Short-term oral contraceptives yielded lower ER and PR contents. Postmenopausal estrogen/progestogen combined therapy yielded lower PR content than estrogen-only therapy.
Keyword
- Estrogen receptor-a
- human breast tissue
- oral contraceptives
- postmenopausal
- progesterone receptor
- premenopausal
Publication and Content Type
- ref (subject category)
- art (subject category)
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