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The T-cell pool is ...
The T-cell pool is anergized in patients with multiple sclerosis in remission
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- Fransson, Moa (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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- Liljenfeldt, Lina S. (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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- Fagius, Jan, 1946- (author)
- Uppsala universitet,Institutionen för neurovetenskap,neurologi
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- Tötterman, Thomas (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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- Loskog, Angelica S. (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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(creator_code:org_t)
- Wiley, 2009
- 2009
- English.
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In: Immunology. - : Wiley. - 0019-2805 .- 1365-2567. ; 126:1, s. 92-101
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Relapsing-remitting multiple sclerosis (RRMS) is a complex autoimmune disease of the central nervous system with oscillating phases of relapse and remission. RRMS has been considered to be driven by T helper type 1 (Th1) lymphocytes but new data indicate the involvement of Th17 responses. In the present study, blood samples from patients (n=48) and healthy individuals (n=44) were evaluated for their immunological status. T cells from patients with RRMS expressed high levels of the activation marker CD28 (P<0.05) and secreted both interferon-gamma (CD8: P<0.05) and interleukin-17 upon polyclonal mitogen or myelin oligodendrocyte glycoprotein antigen stimulation. However, T cells from patients with RRMS in remission, in contrast to relapse, had poor proliferative capacity (P<0.05) suggesting that they are controlled and kept in anergy. This anergy could be broken with CD28 stimulation that restored the T-cell replication. Furthermore, the patients with RRMS had normal levels of CD4(+) Foxp3(+) T regulatory cells but the frequency of Foxp3(+) cells lacking CD127 (interleukin-7 receptor) was lower in patients with MS (mean 12%) compared to healthy controls (mean 29%). Still, regulatory cells (CD25(+) sorted cells) from patients with RRMS displayed no difference in suppressive capacity. In conclusion, patients in relapse/remission demonstrate in vitro T-cell responses that are both Th1 and Th17 that, while in remission, appear to be controlled by tolerogenic mechanisms yet to be investigated.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Neurology
- Neurologi
- Neurology
- Neurologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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