Angiogenesis can be reduced without significant reduction of tumor growth

Svensson, ÅsaUppsala universitet,Institutionen för medicinsk cellbiologi (author)

Background: High risk neuroblastoma (NB) patients have an overall five-year survival of similar to 50%, indicating the need for new treatment strategies, such as angiogenesis inhibition. Materials and Methods: The angiogenesis inhibitor TNP-470 (30 mg/kg, every other day, subcutaneously) was given to nude mice with subcutaneous human neuroblastoma xenografts. The plasma concentrations of the angiogenesis stimulators, i.e. vascular endothelial growth factor A (VEGF-A), fibroblast growth factor 2 (FGF-2) and hepatocyte growth factor (HGF), were assayed longitudinally. Angiogenesis, proliferation and apoptosis were quantified on tumor tissue slides. Results: Upon treatment with TNP-470, angiogenesis was significantly inhibited by the reduction of length and surface area of vessels per tumor volume, without having significant effect on tumor growth, tumor cell proliferation or apoptosis. Plasma concentrations of VEGF-A per tumor volume were significantly increased upon treatment. Conclusion: Angiogenesis inhibition must reach a threshold before significant tumor cell apoptosis and a reduction of the tumor growth rate occur.

Bäckman, UlrikaUppsala universitet,Institutionen för medicinsk cellbiologi (author)
Fuchs, DieterUppsala universitet,Institutionen för medicinsk cellbiologi (author)
Christofferson, RolfUppsala universitet,Institutionen för medicinsk cellbiologi,Institutionen för kirurgiska vetenskaper(Swepub:uu)rolfchri (author)
Azarbayjani, FaranakUppsala universitet,Institutionen för medicinsk cellbiologi (author)
Uppsala universitetInstitutionen för medicinsk cellbiologi (creator_code:org_t)

By the author/editor: Svensson, Åsa; Bäckman, Ulrika; Fuchs, Dieter; Christofferson, ...; Azarbayjani, Far ...

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