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Hippocampal asymmetries and white matter abnormalities on MRI in benign childhood epilepsy with centrotemporal spikes
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- Lundberg, Staffan (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
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- Eeg-Olofsson, Orvar (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
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- Raininko, Raili (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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- Wiley, 1999
- 1999
- English.
- In: Epilepsia. - : Wiley. - 0013-9580 .- 1528-1167. ; 40:12, s. 1808-15
- Journal article (peer-reviewed)
Abstract
Subject headings
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- PURPOSE: To look for brain abnormalities by using magnetic resonance imaging (MRI) in patients with benign childhood epilepsy with centrotemporal spikes (BCECTS), which is the most common epilepsy syndrome in children. METHODS: Eighteen children, aged 6-12 years, with typical BCECTS were examined with MRI, six of them twice. RESULTS: Some hippocampal abnormality was found in six (33%) of the children, all with the syndrome's typical electroencephalogram (EEG) pattern ipsilaterally. Hippocampal size asymmetry was found in five (28%) children (right side < left in two and left < right in three), and high signal intensities on T2-weighted images were found in three (17%). Two children also had other abnormalities; one had a heterotopic nodule near the contralateral frontal horn, and one had an Arnold-Chiari malformation. The hippocampal asymmetry remained unchanged in three of the children who were reexamined after 2 years. High signal intensities on T2-weighted images were seen beneath the cortex-white matter junction in the frontal and temporal lobes of five (28%) children, one of whom also had a hippocampal asymmetry. MRIs were normal in eight (44%) children. CONCLUSION: For the first time, hippocampal asymmetries and white-matter abnormalities have been detectable on the MRIs of children with typical BCECTS. The etiology of the former is unclear, whereas the latter may be a result of a maturational delay involving a defective myelination. Long-term follow-up studies are needed to evaluate the relation between these findings and the clinical course of BCECTS.
Keyword
- Children
- Partial epilepsy
- MRI
- Hippocampus
- White matter
- MEDICINE
- MEDICIN
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- ref (subject category)
- art (subject category)
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