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EGF and dextran-con...
EGF and dextran-conjugated EGF induces differential phosphorylation of the EGF receptor
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- Hägg, Maria (author)
- Uppsala universitet,Enheten för biomedicinsk strålningsvetenskap
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- Liljegren, Åsa (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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- Carlsson, Jörgen (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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- Rönnstrand, Lars (author)
- Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine,Ludwiginstitutet för Cancerforskning
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- Lennartsson, Johan (author)
- Ludwiginstitutet för Cancerforskning
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(creator_code:org_t)
- 2002
- 2002
- English.
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In: International Journal of Molecular Medicine. - 1107-3756 .- 1791-244X. ; 10:5, s. 655-659
- Related links:
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Dextran-conjugated EGF (EGF-dextran) has a potential use for targeted radionuclide therapy of tumors that overexpress the epidermal growth factor receptor (EGFR). There are plans to treat both bladder carcinomas and malignant gliomas with local injections of radiolabeled EGF-dextran since these tumors often express high levels of EGFR. In this report we show that EGF and EGF-dextran differentially activate the EGFR. In the human glioma cell line U-343, activation of the serine/threonine kinases Erk and Akt is identical upon stimulation with EGF or EGF-dextran. However, the effect on phospholipase Cgamma1 (PLCgamma1) phosphorylation differs. In cells stimulated with EGF-dextran, the PLCgamma1 phosphorylation is lower than in cells stimulated with EGF. This observation could be explained by the fact that the PLCgamma1 association sites in the EGFR, tyrosine residues 992 and 1173, were phosphorylated to a lower degree when the receptor was stimulated with EGF-dextran as compared to with EGF.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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