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Effects of chronic ...
Effects of chronic stress on the immune response to oral human serum albumin-conjugated starch microparticles in rats
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- Keita, Asa V. (author)
- Linköpings universitet,Kirurgi,Hälsouniversitetet
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- Stertman, Linda (author)
- Uppsala universitet,Institutionen för farmaci,Uppsala University
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- Sun, Yi-Qian (author)
- Linköpings universitet,Hälsouniversitetet,Kirurgi
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- Larhed, Agneta (author)
- Uppsala universitet,Institutionen för farmaci,Uppsala University
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- Sjöholm, Ingvar (author)
- Uppsala universitet,Institutionen för farmaci,Uppsala University
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- Söderholm, Johan D (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Kirurgi,Kirurgiska kliniken i Östergötland med verksamhet i Linköping, Norrköping och Motala
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(creator_code:org_t)
- Elsevier BV, 2007
- 2007
- English.
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In: Journal of Neuroimmunology. - : Elsevier BV. - 0165-5728 .- 1872-8421. ; 183:1-2, s. 33-42
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Uptake of antigens and bacteria over the follicle-associated epithelium (FAE) is increased after chronic psychological stress. We investigated whether stress affects the immune response to particle-conjugated antigens taken up via the FAE. Rats were submitted to two 10-day periods of water avoidance stress and orally immunized during these periods. Stressed immunized rats displayed altered cell populations and a Th1-skewed immune response within the lymphoid follicles, together with enhanced delayed-type hypersensitivity. We conclude that chronic stress affects the cell-mediated immune response after oral immunization, which may have implications for the understanding of allergic and autoimmune diseases and development of oral vaccines.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- Administration; Oral
- Animals
- Antigens; CD8/metabolism
- Antigens; Differentiation/metabolism
- Chronic Disease
- Cytokines/metabolism
- Enzyme-Linked Immunosorbent Assay/methods
- Flow Cytometry/methods
- Gene Expression Regulation/physiology
- Humans
- Hypersensitivity; Delayed/etiology/immunology
- Male
- Peyer's Patches/immunology/metabolism
- Rats
- Rats; Wistar
- Serum Albumin/administration & dosage/*immunology
- Starch/*administration & dosage/immunology
- Stress; Psychological/*immunology/pathology
- Time Factors
- MEDICINE
- MEDICIN
- PHARMACY
- FARMACI
Publication and Content Type
- ref (subject category)
- art (subject category)
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