onr:"swepub:oai:DiVA.org:uu-93511"
Search: onr:"swepub:oai:DiVA.org:uu-93511" > Effects of Dehydroe...
- 1 of 1
- Previous record
- Next record
- To hitlist
Effects of Dehydroepiandrosterone Supplement on Health-related Quality of Life in Glucocorticoid Treated Female Patients with Systemic Lupus Erythematosus
-
- Nordmark, Gunnel (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,systemisk autoimmunitet
-
- Bengtsson, Christine (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Larsson, Anders (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Biologiska membran
- show more...
- show less...
- (creator_code:org_t)
- 2009-07-07
- 2005
- English.
- In: Autoimmunity. - : Informa UK Limited. - 0891-6934 .- 1607-842X. ; 38:7, s. 531-540
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- The objective of this study was to evaluate the efficacy of low dose dehydroepiandrosterone (DHEA) on health-related quality of life (HRQOL) in glucocorticoid treated female patients with systemic lupus erythematosus (SLE). Forty one women ( >or= 5 mg prednisolone/day) were included in a double-blind, randomized, placebo-controlled study for 6 months where DHEA was given at 30 mg/20 mg ( or= 46 years) daily, or placebo, followed by 6 months open DHEA treatment to all patients. HRQOL was assessed at baseline, 6 and 12 months, using four validated questionnaires and the patients' partners completed a questionnaire assessing mood and behaviour at 6 months. DHEA treatment increased serum levels of sulphated DHEA from subnormal to normal. The DHEA group improved in SF-36 "role emotional" and HSCL-56 total score (both p<0.05). During open DHEA treatment, the former placebo group improved in SF-36 "mental health" (p<0.05) with a tendency for improvement in HSCL-56 total score (p=0.10). Both groups improved in McCoy's Sex Scale during active treatment (p<0.05). DHEA replacement decreased high-density lipoprotein (HDL) cholesterol and increased insulin-like growth factor I (IGF-I) and haematocrit. There were no effects on bone density or disease activity and no serious adverse events. Side effects were mild. We conclude that low dose DHEA treatment improves HRQOL with regard to mental well-being and sexuality and can be offered to women with SLE where mental distress and/or impaired sexuality constitutes a problem.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Adjuvants; Immunologic/pharmacology/*therapeutic use
- Adult
- Aged
- Androgens/blood
- Corticotropin/blood
- Dehydroepiandrosterone/pharmacology/*therapeutic use
- Double-Blind Method
- Female
- Humans
- Insulin-Like Growth Factor I/metabolism
- Lupus Erythematosus; Systemic/blood/*drug therapy/*physiopathology
- Middle Aged
- Prednisolone/pharmacology/*therapeutic use
- Quality of Life
- Research Support; Non-U.S. Gov't
- Sex Characteristics
- Sex Hormone-Binding Globulin/metabolism
- health-related quality of life
- SLE
- DHEA
- glucocorticoid
Publication and Content Type
- ref (subject category)
- art (subject category)
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Nordmark, Gunnel
- Bengtsson, Chris ...
- Larsson, Anders
- Karlsson, Anders
- Sturfelt, Gunnar
- Rönnblom, Lars
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Rheumatology and ...
- Articles in the publication
- Autoimmunity
- By the university
- Uppsala University
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
