SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:uu-93511"
 

Search: onr:"swepub:oai:DiVA.org:uu-93511" > Effects of Dehydroe...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Nordmark, GunnelUppsala universitet,Institutionen för medicinska vetenskaper,systemisk autoimmunitet (author)

Effects of Dehydroepiandrosterone Supplement on Health-related Quality of Life in Glucocorticoid Treated Female Patients with Systemic Lupus Erythematosus

  • Article/chapterEnglish2005

Publisher, publication year, extent ...

  • 2009-07-07
  • Informa UK Limited,2005
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-93511
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-93511URI
  • https://doi.org/10.1080/08916930500285550DOI
  • https://lup.lub.lu.se/record/211224URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The objective of this study was to evaluate the efficacy of low dose dehydroepiandrosterone (DHEA) on health-related quality of life (HRQOL) in glucocorticoid treated female patients with systemic lupus erythematosus (SLE). Forty one women ( >or= 5 mg prednisolone/day) were included in a double-blind, randomized, placebo-controlled study for 6 months where DHEA was given at 30 mg/20 mg ( or= 46 years) daily, or placebo, followed by 6 months open DHEA treatment to all patients. HRQOL was assessed at baseline, 6 and 12 months, using four validated questionnaires and the patients' partners completed a questionnaire assessing mood and behaviour at 6 months. DHEA treatment increased serum levels of sulphated DHEA from subnormal to normal. The DHEA group improved in SF-36 "role emotional" and HSCL-56 total score (both p<0.05). During open DHEA treatment, the former placebo group improved in SF-36 "mental health" (p<0.05) with a tendency for improvement in HSCL-56 total score (p=0.10). Both groups improved in McCoy's Sex Scale during active treatment (p<0.05). DHEA replacement decreased high-density lipoprotein (HDL) cholesterol and increased insulin-like growth factor I (IGF-I) and haematocrit. There were no effects on bone density or disease activity and no serious adverse events. Side effects were mild. We conclude that low dose DHEA treatment improves HRQOL with regard to mental well-being and sexuality and can be offered to women with SLE where mental distress and/or impaired sexuality constitutes a problem.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Bengtsson, ChristineLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-cbe (author)
  • Larsson, AndersUppsala universitet,Institutionen för medicinska vetenskaper,Biologiska membran(Swepub:uu)anderska (author)
  • Karlsson, AndersUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)anderska (author)
  • Sturfelt, GunnarLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-gst (author)
  • Rönnblom, LarsUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)larsronn (author)
  • Uppsala universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Related titles

  • In:Autoimmunity: Informa UK Limited38:7, s. 531-5400891-69341607-842X

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Search outside SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view