Cadmium-induced gene expression changes in the mouse embryo, and the influence of pretreatment with zinc

Fernández, Estíbaliz L. (author): Uppsala universitet,Avdelningen för toxikologi

Gustafson, Anne-Lee (author)

(creator_code:org_t)

Elsevier BV, 2006
2006
English.
In: Reproductive Toxicology. - : Elsevier BV. - 0890-6238 .- 1873-1708. ; 22:4, s. 636-646

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; show less...

Abstract Subject headings

Cadmium (Cd) administered to female C57BL/6 mice on gestation day 8 induces a high incidence of anterior neural tube defects (exencephaly). This adverse effect can be attenuated by maternal pretreatment with zinc (Zn). In this study we used replicated microarray analysis and real-time PCR to investigate gene expression changes induced in the embryo 5 and 10h after maternal Cd exposure in the absence or presence of Zn pretreatment. We report nine genes with a transcriptional response induced by Cd, none of which was influenced by Zn pretreatment, and two genes induced only by combined matemal Cd exposure and Zn pretreatment. We discuss the results in relation to the possibility that Cd is largely excluded from the embryo, that the teratogenic effects of Cd may be secondary to toxicity in extraembryonic tissues, and that the primary protective role of Zn may not be to reverse Cd-induced transcription in the embryo.

By the author/editor: Kultima, Kim; Fernández, Estíb ...; Scholz, Birger; Gustafson, Anne- ...; Dencker, Lennart; Stigson, Michael

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Pharmaceutical S ...

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