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Origin of the prola...
Origin of the prolactin-releasing hormone (PRLH) receptors : Evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution
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- Lagerström, Malin C. (author)
- Uppsala universitet,Institutionen för neurovetenskap,Farmakologi 3
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- Fredriksson, Robert (author)
- Uppsala universitet,Institutionen för neurovetenskap,Farmakologi 3
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- Bjarnadottir, Thora (author)
- Uppsala universitet,Institutionen för neurovetenskap,Farmakologi 3
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- Fridmanis, Davids (author)
- Uppsala universitet,Institutionen för neurovetenskap,Farmakologi 3
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- Holmquist, Tomas (author)
- Uppsala universitet,Institutionen för neurovetenskap,Farmakologi 3
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- Andersson, Jan (author)
- Karolinska Institutet,Uppsala universitet,Institutionen för neurovetenskap,Farmakologi 3
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Yan, Yi-Lin (author)
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Raudsepp, Terje (author)
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Zoorob, Rima (author)
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- Kukkonen, Jyrki P. (author)
- Uppsala universitet,Institutionen för neurovetenskap,Farmakologi 3
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- Lundin, LG (author)
- Uppsala universitet,Institutionen för neurovetenskap,Farmakologi 3
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- Klovins, J (author)
- Uppsala universitet,Institutionen för neurovetenskap,Farmakologi 3
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Chowdhary, BP (author)
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Pistlethwait, JH (author)
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- Schiöth, Helgi (author)
- Uppsala universitet,Institutionen för neurovetenskap,Farmakologi 3
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(creator_code:org_t)
- Elsevier BV, 2005
- 2005
- English.
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In: Genomics. - : Elsevier BV. - 0888-7543 .- 1089-8646. ; 85:6, s. 688-703
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https://doi.org/10.1...
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Abstract
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- We present seven new vertebrate homologs of the prolactin-releasing hormone receptor (PRLHR) and show that these are found as two separate subtypes, PRLHR1 and PRLHR2. Analysis of a number of vertebrate sequences using phylogeny, pharmacology, and paralogon analysis indicates that the PRLHRs are likely to share a common ancestry with the neuropeptide Y (NPY) receptors. Moreover, a micromolar level of NPY was able to bind and inhibit completely the PRLH-evoked response in PRLHR1-expressing cells. We suggest that an ancestral PRLH peptide started coevolving with a redundant NPY binding receptor, which then became PRLHR, approximately 500 million years ago. The PRLHR1 subtype was shown to have a relatively high evolutionary rate compared to receptors with fixed peptide preference, which could indicate a drastic change in binding preference, thus supporting this hypothesis. This report suggests how gene duplication events can lead to novel peptide ligand/receptor interactions and hence spur the evolution of new physiological functions.
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Genomics
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- By the author/editor
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Lagerström, Mali ...
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Fredriksson, Rob ...
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Bjarnadottir, Th ...
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Fridmanis, David ...
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Holmquist, Tomas
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Andersson, Jan
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show more...
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Yan, Yi-Lin
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Raudsepp, Terje
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Zoorob, Rima
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Kukkonen, Jyrki ...
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Lundin, LG
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Klovins, J
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Chowdhary, BP
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Pistlethwait, JH
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Schiöth, Helgi
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show less...
- Articles in the publication
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Genomics
- By the university
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Uppsala University
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Karolinska Institutet