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A look inside HIV r...
A look inside HIV resistance through retroviral protease interaction maps
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- Kontijevskis, Aleksejs (author)
- Uppsala universitet,Centrum för bioinformatik,Institutionen för farmaceutisk biovetenskap
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- Prusis, Peteris (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Petrovska, Ramona (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Yahorava, Sviatlana (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Mutulis, Felikss (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Mutule, Ilze (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Komorowski, Jan (author)
- Uppsala universitet,Centrum för bioinformatik
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- Wikberg, Jarl (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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(creator_code:org_t)
- 2007-03-09
- 2007
- English.
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In: PloS Computational Biology. - : Public Library of Science (PLoS). - 1553-734X .- 1553-7358. ; 3:3, s. 424-435
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Retroviruses affect a large number of species, from fish and birds to mammals and humans, with global socioeconomic negative impacts. Here the authors report and experimentally validate a novel approach for the analysis of the molecular networks that are involved in the recognition of substrates by retroviral proteases. Using multivariate analysis of the sequence-based physiochemical descriptions of 61 retroviral proteases comprising wild-type proteases, natural mutants, and drug-resistant forms of proteases from nine different viral species in relation to their ability to cleave 299 substrates, the authors mapped the physicochemical properties and cross-dependencies of the amino acids of the proteases and their substrates, which revealed a complex molecular interaction network of substrate recognition and cleavage. The approach allowed a detailed analysis of the molecular-chemical mechanisms involved in substrate cleavage by retroviral proteases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- Proteochemometrics
- HIV
- resistance
- drug discovery
- PLS
- protein-ligand interactions
- PHARMACY
- FARMACI
Publication and Content Type
- ref (subject category)
- art (subject category)
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