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  • Abelson, Anna-KarinUppsala universitet,Institutionen för genetik och patologi (author)

No evidence of association between genetic variants of the PDCD1 ligands and SLE

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • 2006-11-30
  • Springer Science and Business Media LLC,2007
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-97760
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-97760URI
  • https://doi.org/10.1038/sj.gene.6364360DOI
  • https://lup.lub.lu.se/record/676295URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:13929807URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • PDCD1, an immunoreceptor involved in peripheral tolerance has previously been shown to be genetically associated with systemic lupus erythematosus (SLE). PDCD1 has two ligands whose genes are located in close proximity on chromosome 9p24. Our attention was drawn to these ligands after finding suggestive linkage to a marker (gata62f03, Z=2.27) located close to their genes in a genome scan of Icelandic families multiplex for SLE. Here, we analyse Swedish trios (N=149) for 23 single nucleotide polymorphisms (SNPs) within the genes of the PDCD1 ligands. Initially, indication of association to eight SNPs was observed, and these SNPs were therefore also analysed in Mexican trios (N=90), as well as independent sets of patients and controls from Sweden (152 patients, 448 controls) and Argentina (288 patients, 288 controls). We do not find support for genetic association to SLE. This is the first genetic study of SLE and the PDCD1 ligands and the lack of association in several cohorts implies that these genes are not major risk factors for SLE.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Johansson, Cecilia M.Uppsala universitet,Institutionen för genetik och patologi (author)
  • Kozyrev, Sergey V.Uppsala universitet,Institutionen för genetik och patologi(Swepub:uu)sekoz957 (author)
  • Kristjansdottir, HelgaUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)helkr245 (author)
  • Gunnarsson, IvaKarolinska Institutet (author)
  • Svenungsson, ElisabetKarolinska Institutet (author)
  • Jönsen, AndreasLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-ajo (author)
  • Lima, Guadalupe (author)
  • Scherbarth, Hugo R (author)
  • Gamron, Susana (author)
  • Allievi, Alejandro (author)
  • Palatnik, Sergio A (author)
  • Alvarellos, Antonio (author)
  • Paira, Sergio (author)
  • Graf, Cesar (author)
  • Guillerón, Carlos (author)
  • Catoggio, Luis J (author)
  • Prigione, Carlos (author)
  • Battagliotti, Cesar G (author)
  • Berbotto, Guillermo A (author)
  • García, Mercedes A (author)
  • Perandones, Carlos E (author)
  • Truedsson, Lennart (author)
  • Steinsson, Kristjan (author)
  • Sturfelt, GunnarLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-gst (author)
  • Pons-Estel, Bernardo (author)
  • Alarcón-Riquelme, Marta E.Uppsala universitet,Institutionen för genetik och patologi(Swepub:uu)martaala (author)
  • Garcia, Ma (author)
  • Grp, Argentinean Collaborative (author)
  • Uppsala universitetInstitutionen för genetik och patologi (creator_code:org_t)

Related titles

  • In:Genes and Immunity: Springer Science and Business Media LLC8:1, s. 69-741466-48791476-5470

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