SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:uu-97804"
 

Search: onr:"swepub:oai:DiVA.org:uu-97804" > Does APOE explain t...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Blom, Elin SusanneUppsala universitet,Geriatrik (author)

Does APOE explain the linkage of Alzheimer’s disease to chromosome 19q13?

  • Article/chapterEnglish2008

Publisher, publication year, extent ...

  • 2007-12-27
  • Wiley,2008
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-97804
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-97804URI
  • https://doi.org/10.1002/ajmg.b.30681DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:117572934URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • We have studied the impact of the apolipoprotein E gene (APOE) on the chromosome 19 linkage peak from an analysis of sib-pairs affected by Alzheimer's disease. We genotyped 417 affected sib-pairs (ASPs) collected in Sweden and Norway (SWE), the UK and the USA for 10 microsatellite markers on chromosome 19. The highest Zlr (3.28, chromosome-wide P-value 0.036) from the multi-point linkage analysis was located approximately 1 Mb from APOE, at marker D19S178. The linkage to chromosome 19 was well explained by APOE in the whole sample as well as in the UK and USA subsamples, as identity by descent (IBD) increased with the number of epsilon 4 alleles in ASPs. There was a suggestion from the SWE subsample that linkage was higher than would be expected from APOE alone, although the test for this did not reach formal statistical significance. There was also a significant age at onset (aao) effect on linkage to chromosome 19q13 in the whole sample, which manifested itself as increased IBD sharing in relative pairs with lower mean aao. This effect was partially, although not completely, explained by APOE. The aao effect varied considerably between the different subsamples, with most of the effect coming from the UK sample. The other samples showed smaller effects in the same direction, but these were not significant.

Subject headings and genre

  • Alzheimer's disease
  • APOE
  • linkage
  • age at onset
  • apolipoprotein E
  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Holmans, Peter (author)
  • Arepalli, Sampath (author)
  • Adighibe, Omanma (author)
  • Hamshere, Marian L. (author)
  • Gatz, Margaret (author)
  • Pedersen, Nancy L.Karolinska Institutet (author)
  • Bergem, A. L. Mina (author)
  • Owen, Michael J. (author)
  • Hollingworth, Paul (author)
  • Goate, Alison (author)
  • Williams, Julie (author)
  • Lannfelt, LarsUppsala universitet,Geriatrik(Swepub:uu)lalan021 (author)
  • Hardy, John (author)
  • Wavrant-De Vrièze, Fabienne (author)
  • Glaser, AnnaUppsala universitet,Geriatrik(Swepub:uu)angla622 (author)
  • Uppsala universitetGeriatrik (creator_code:org_t)

Related titles

  • In:American Journal of Medical Genetics Part B: Neuropsychiatric Genetics American Journal of Medical Genetics Part B: Neuropsychiatric Genetics: Wiley147B:6, s. 778-831552-485X
  • In:American Journal of Medical Genetics Part B: Neuropsychiatric Genetics: Wiley147B:6, s. 778-831552-4841

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view