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Isolation and properties of the CYP2D25 promoter : Transcriptional regulation by vitamin D3 metabolites
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- Ellfolk, Maria (author)
- Uppsala universitet,Biokemi
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- Norlin, Maria (author)
- Uppsala universitet,Biokemi
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- Wikvall, Kjell (author)
- Uppsala universitet,Biokemi
- (creator_code:org_t)
- Elsevier BV, 2006
- 2006
- English.
- In: Biochemical and Biophysical Research Communications - BBRC. - : Elsevier BV. - 0006-291X .- 1090-2104. ; 345:2, s. 568-572
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Previous studies have suggested that hepatic production of 25-hydroxyvitamin D3 may be suppressed by 1α,25-dihydroxyvitamin D3. However, the molecular details of these observations have not been clarified. In the current study, the 5´-flanking DNA sequence of CYP2D25, a porcine microsomal vitamin D 25-hydroxylase, was isolated and analyzed. The CYP2D25 promoter contains a putative vitamin D response element (VDRE). The promoter activity was markedly suppressed by 1α,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 in presence of vitamin D receptor (VDR). The data suggest that VDR-mediated inhibition of 25-hydroxylase(s) by vitamin D3 metabolites at the transcriptional level may play an important role in the regulation of 25-hydroxyvitamin D3 production in liver and other tissues.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- Vitamin D3
- 25-Hydroxylase
- CYP2D25
- Promoter
- Transcriptional regulation
- PHARMACY
- FARMACI
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Norlin, Maria
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