IgE sensitisation in relation to flow-independent nitric oxide exchange parameters

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Malinovschi, AndreiUppsala universitet,Integrativ Fysiologi,Department of Medical Cell Biology: Integrative Physiology, Uppsala University, Uppsala, Sweden (author)

IgE sensitisation in relation to flow-independent nitric oxide exchange parameters

Article/chapterEnglish2006

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2006-06-20
Springer Science and Business Media LLC,2006
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LIBRIS-ID:oai:DiVA.org:uu-97884
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-97884URI
https://doi.org/10.1186/1465-9921-7-92DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-22669URI

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Language:English
Summary in:English

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Background: A positive association between IgE sensitisation and exhaled NO levels has been found in several studies, but there are no reports on the compartment of the lung that is responsible for the increase in exhaled NO levels seen in IgE-sensitised subjects.Methods: The present study comprised 288 adult subjects from the European Community Respiratory Health Survey II who were investigated in terms of lung function, IgE sensitisation ( sum of specific IgE), smoking history and presence of rhinitis and asthma. Mean airway tissue concentration of NO (Caw(NO)), airway transfer factor for NO (Daw(NO)), mean alveolar concentration of NO (Calv(NO)) and fractional exhaled concentration of NO at a flow rate of 50 mL s(-1) ( FENO0.05) were determined using the extended NO analysis.Results: IgE-sensitised subjects had higher levels ( geometric mean) of FENO 0.05 (24.9 vs. 17.3 ppb) ( p < 0.001), Daw(NO) ( 10.5 vs. 8 mL s(-1)) ( p = 0.02) and Caw(NO) (124 vs. 107 ppb) ( p < 0.001) and positive correlations were found between the sum of specific IgE and FENO 0.05, Caw(NO) and Daw(NO) levels ( p < 0.001 for all correlations). Sensitisation to cat allergen was the major determinant of exhaled NO when adjusting for type of sensitisation. Rhinitis and asthma were not associated with the increase in exhaled NO variables after adjusting for the degree of IgE sensitisation.Conclusion: The presence of IgE sensitisation and the degree of allergic sensitisation were related to the increase in airway NO transfer factor and the increase in NO concentration in the airway wall. Sensitisation to cat allergen was related to the highest increases in exhaled NO parameters. Our data suggest that exhaled NO is more a specific marker of allergic inflammation than a marker of asthma or rhinitis.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Lungmedicin och allergi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Respiratory Medicine and Allergy hsv//eng
MEDICINE
MEDICIN

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Janson, ChristerUppsala universitet,Lungmedicin och allergologi,Asthma and Allergy Research Centre, Uppsala University, Uppsala, Sweden; Department of Medical Sciences: Respiratory Medicine and Allergology, Uppsala University, Uppsala, Sweden(Swepub:uu)chrisjn (author)
Holmkvist, ThomasUppsala universitet,Integrativ Fysiologi,Department of Medical Cell Biology: Integrative Physiology, Uppsala University, Uppsala, Sweden (author)
Norbäck, DanUppsala universitet,Arbets- och miljömedicin,Asthma and Allergy Research Centre, Uppsala University, Uppsala, Sweden; Department of Medical Sciences: Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden (author)
Meriläinen, PekkaDepartment of Engineering Physics and Mathematics, Helsinki University of Technology, Helsinki, Finland (author)
Högman, MarieannHögskolan i Gävle,Uppsala universitet,Integrativ Fysiologi,Centrum för klinisk forskning, Gävleborg,Ämnesavdelningen för medicinsk vetenskap,Asthma and Allergy Research Centre, Uppsala University, Uppsala, Sweden; Department of Medical Cell Biology: Integrative Physiology, Uppsala University, Uppsala, Sweden(Swepub:uu)marihogm (author)
Uppsala universitetIntegrativ Fysiologi (creator_code:org_t)

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In:Respiratory Research: Springer Science and Business Media LLC7, s. 92-1465-99211465-993X

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