Search: onr:"swepub:oai:DiVA.org:uu-97897" >
Stereotyped pattern...
Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia : implications for the role of antigen selection in leukemogenesis
-
- Murray, Fiona (author)
- Uppsala universitet,Institutionen för genetik och patologi
-
Darzentas, Nikos (author)
-
Hadzidimitriou, Anastasia (author)
-
show more...
-
- Tobin, Gerard (author)
- Uppsala universitet,Institutionen för genetik och patologi
-
Boudjogra, Myriam (author)
-
Scielzo, Cristina (author)
-
Laoutaris, Nikolaos (author)
-
- Karlsson, Karin (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
-
Baran-Marzsak, Fanny (author)
-
Tsaftaris, Athanasios (author)
-
Moreno, Carol (author)
-
Anagnostopoulos, Achilles (author)
-
Caligaris-Cappio, Federico (author)
-
Vaur, Dominique (author)
-
Ouzounis, Christos (author)
-
Belessi, Chrysoula (author)
-
Ghia, Paolo (author)
-
Davi, Fred (author)
-
- Rosenquist, Richard (author)
- Uppsala universitet,Institutionen för genetik och patologi
-
Stamatopoulos, Kostas (author)
-
show less...
-
(creator_code:org_t)
- American Society of Hematology, 2008
- 2008
- English.
-
In: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 111:3, s. 1524-1533
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
show less...
Abstract
Subject headings
Close
- Somatic hypermutation (SHM) features in a series of 1967 immunoglobulin heavy chain gene (IGH) rearrangements obtained from patients with chronic lymphocytic leukemia (CLL) were examined and compared with IGH sequences from non-CLL B cells available in public databases. SHM analysis was performed for all 1290 CLL sequences in this cohort with less than 100% identity to germ line. At the cohort level, SHM patterns were typical of a canonical SHM process. However, important differences emerged from the analysis of certain subgroups of CLL sequences defined by: (1) IGHV gene usage, (2) presence of stereotyped heavy chain complementarity-determining region 3 (HCDR3) sequences, and (3) mutational load. Recurrent, "stereotyped" amino acid changes occurred across the entire IGHV region in CLL subsets carrying stereotyped HCDR3 sequences, especially those expressing the IGHV3-21 and IGHV4-34 genes. These mutations are un-derrepresented among non-CLL sequences and thus can be considered as CLL-biased. Furthermore, it was shown that even a low level of mutations may be functionally relevant, given that stereotyped amino acid changes can be found in subsets of minimally mutated cases. The precise targeting and distinctive features of somatic hypermutation (SHM) in selected subgroups of CLL patients provide further evidence for selection by specific antigenic element(s).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Blood
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Murray, Fiona
-
Darzentas, Nikos
-
Hadzidimitriou, ...
-
Tobin, Gerard
-
Boudjogra, Myria ...
-
Scielzo, Cristin ...
-
show more...
-
Laoutaris, Nikol ...
-
Karlsson, Karin
-
Baran-Marzsak, F ...
-
Tsaftaris, Athan ...
-
Moreno, Carol
-
Anagnostopoulos, ...
-
Caligaris-Cappio ...
-
Vaur, Dominique
-
Ouzounis, Christ ...
-
Belessi, Chrysou ...
-
Ghia, Paolo
-
Davi, Fred
-
Rosenquist, Rich ...
-
Stamatopoulos, K ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Hematology
- Articles in the publication
-
Blood
- By the university
-
Uppsala University
-
Lund University