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The Role of Circula...
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Bolander, ÅsaUppsala universitet,Enheten för onkologi
(author)
The Role of Circulating Angiogenic Factors in Patients Operated on for Localized Malignant Melanoma
- Article/chapterEnglish2007
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-97931
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-97931URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Malignant melanoma is a disease capable of rapid progression and rapidly developing metastases. Angiogenesis is a key event signalling tumour progression and elevated levels of angiogenic markers may indicate metastatic disease. No previously published work has, so far, examined plasma vascular endothelial growth factor (VEGF) and its receptor, VEGFR-1, in melanoma. This study investigated circulating levels of the angiogenic factors, VEGF-A and -D, their receptors 1-3 and hepatocyte growth factor (HGF)/scatter factor, in patients shortly after primary surgery for localized malignant melanoma. Elevated circulating levels of VEGF and its receptors, and of HGF, were found postoperatively, possibly derived from the reactive stroma adjacent to the tumours. Using univariate analysis, a correlation between levels of VEGFR-1 and relapse was found, but a correlation between the investigated angiogenic factors and survival could not be established. The results of the present study indicate that production of these angiogenic factors may be due to sources other than malignant melanoma cells.
Subject headings and genre
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Malignant melanoma
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angiogenesis
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survival
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relapse
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vascular endothelial growth factor
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hepatocyte growth factor
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hepatocyte scatter factor
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MEDICINE
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MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
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Wagenius, GunnarUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Lunggruppen(Swepub:uu)gunnwage
(author)
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Larsson, AndersUppsala universitet,Klinisk kemi,Biologisk struktur och funktion(Swepub:uu)andlarss
(author)
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Brattström, DanielUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Lymfomgruppen(Swepub:uu)danibrat
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Ullenhag, GustavUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi(Swepub:uu)gustulle
(author)
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Hesselius, PatrikUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi(Swepub:uu)patrhess
(author)
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Ekman, SimonUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Lunggruppen
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Bergqvist, MichaelUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Lunggruppen(Swepub:uu)michberg
(author)
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Uppsala universitetEnheten för onkologi
(creator_code:org_t)
Related titles
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In:Anticancer Research27:5A, s. 3211-32170250-70051791-7530
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