Search: onr:"swepub:oai:DiVA.org:uu-98661" >
Type I collagen alp...
Type I collagen alpha1 Sp1 polymorphism and the risk of cruciate ligament ruptures or shoulder dislocations
-
- Khoschnau, Shwan (author)
- Uppsala universitet,Ortopedi
-
- Melhus, Håkan (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
-
- Jacobson, Annica (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
-
show more...
-
- Rahme, Hans (author)
- Uppsala universitet,Ortopedi
-
- Bengtsson, Henrik (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
-
- Ribom, Eva (author)
- Uppsala universitet,Ortopedi
-
- Grundberg, Elin (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
-
- Mallmin, Hans (author)
- Uppsala universitet,Ortopedi
-
- Michaëlsson, Karl (author)
- Uppsala universitet,Ortopedi
-
show less...
-
(creator_code:org_t)
- 2008-07-31
- 2008
- English.
-
In: American Journal of Sports Medicine. - : SAGE Publications. - 0363-5465 .- 1552-3365. ; 36:12, s. 2432-2436
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- BACKGROUND: Cruciate ligament ruptures and shoulder dislocations are often caused by trauma, but predisposing intrinsic factors might also influence the risk. These injuries are more common in those with a previously injured sibling, an observation that might indicate a genetic predisposition. It is well known that polymorphisms in the collagen I gene are associated not only with osteoporosis and osteoporotic fracture risk, but also with osteoarthritis. HYPOTHESIS: Because collagen I is abundant in ligaments and tendons, the authors hypothesized that collagen I alpha1 Sp1 polymorphism also was related to the occurrence of cruciate ligament ruptures and shoulder dislocations. STUDY DESIGN: Case-control study; Level of evidence, 3. METHODS: A total of 358 patients and 325 randomly selected population-based female controls were included in the study. Of the cases, 233 had a cruciate ligament rupture and 126 had had a shoulder dislocation. Age-adjusted odds ratios (ORs) with 95% confidence intervals (CIs) estimated by unconditional logistic regression were used as measures of association. RESULTS: Compared with the homozygous SS category, the heterozygous participants displayed a similar risk (OR, 1.06; 95% CI, 0.76-1.49), whereas the ss genotype was underrepresented in the injured population compared with the controls (OR, 0.15; 95% CI, 0.03-0.68). This latter estimate was similar for both cruciate ligament ruptures and shoulder dislocations, and was furthermore not modified by general joint laxity. CONCLUSION: The authors found a substantially decreased risk of these injuries associated with collagen type I alpha1 Sp1 polymorphism. The study might encourage other investigators to consider further research in the area of genes and soft tissue injuries.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- cruciate ligament rupture
- shoulder dislocation
- polymorphism
- gene
- collagen
- MEDICINE
- MEDICIN
- Orthopaedics
- Ortopedi
- Orthopaedics
- Ortopedi
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database