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Novel genetic varia...
Novel genetic variant in FTO influences insulin levels and insulin resistance in severely obese children and adolescents.
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- Jacobsson, J. A. (author)
- Uppsala universitet,Funktionell farmakologi,Institutionen för neurovetenskap
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- Klovins, Janis (author)
- Uppsala universitet,Institutionen för neurovetenskap
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- Kapa, I. (author)
- Uppsala universitet,Institutionen för neurovetenskap
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- Danielsson, P (author)
- Karolinska Institutet
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- Svensson, V (author)
- Karolinska Institutet
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- Ridderstråle, Martin (author)
- Lund University,Lunds universitet,Diabetes - klinisk obesitasforskning,Forskargrupper vid Lunds universitet,Diabetes - Clinical Obesity,Lund University Research Groups
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- Gyllensten, Ulf (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Marcus, C (author)
- Karolinska Institutet
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- Fredriksson, R. (author)
- Uppsala universitet,Funktionell farmakologi,Institutionen för neurovetenskap
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- Schiöth, Helgi B. (author)
- Uppsala universitet,Funktionell farmakologi,Institutionen för neurovetenskap
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(creator_code:org_t)
- 2008-09-16
- 2008
- English.
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In: International Journal of Obesity. - : Springer Science and Business Media LLC. - 0307-0565 .- 1476-5497. ; 32:11, s. 1730-1735
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Abstract
Subject headings
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- BACKGROUND The global prevalence of obesity and overweight is increasing rapidly among adults as well as among children and adolescents. Recent genome-wide association studies have provided strong support for association between variants in the FTO gene and obesity. We sequenced regions of the FTO gene to identify novel variants that are associated with obesity and related metabolic traits. RESULTS We screened exons 3 and 4 including exon-intron boundaries in FTO in 48 obese children and adolescents and identified three novel single nucleotide polymorphism in the fourth intronic region, (c.896+37A>G, c.896+117C>G and c.896+223A>G). We further genotyped c.896+223A>G in 962 subjects, 450 well-characterized obese children and adolescents and 512 adolescents with normal weight. Evidence for differences in genotype frequencies were not detected for the c.896+223A>G variant between extremely obese children and adolescents and normal weight adolescents (P=0.406, OR=1.154 (0.768-1.736)). Obese subjects with the GG genotype, however, had 30% increased fasting serum insulin levels (P=0.017) and increased degree of insulin resistance (P=0.025). There were in addition no differences in body mass index (BMI) or BMI standard deviation score (SDS) levels among the obese subjects according to genotype and the associations with insulin levels and insulin resistance remained significant when adjusting for BMI SDS. CONCLUSION These findings suggest that this novel variant in FTO is affecting metabolic phenotypes such as insulin resistance, which are not mediated through differences in BMI levels.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- FTO
- polymorphism
- metabolic phenotypes
- children
- adolescents
- MEDICINE
- MEDICIN
- adolescents
- children
- metabolic phenotypes
- FTO
- polymorphism
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Jacobsson, J. A.
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Klovins, Janis
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Kapa, I.
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Danielsson, P
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Svensson, V
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Ridderstråle, Ma ...
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show more...
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Gyllensten, Ulf
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Marcus, C
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Fredriksson, R.
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Schiöth, Helgi B ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
- Articles in the publication
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International Jo ...
- By the university
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Uppsala University
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Lund University
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Karolinska Institutet