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Major gender differ...
Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes.
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- Jacobsson, Josefin A. (author)
- Uppsala universitet,Funktionell farmakologi,Institutionen för neurovetenskap
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- Danielsson, Pernilla (author)
- Karolinska Institutet
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- Svensson, Victoria (author)
- Karolinska Institutet
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- Klovins, Janis (author)
- Uppsala universitet,Institutionen för neurovetenskap
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- Gyllensten, Ulf (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Marcus, Claude (author)
- Karolinska Institutet
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- Schiöth, Helgi B. (author)
- Uppsala universitet,Funktionell farmakologi,Institutionen för neurovetenskap
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- Fredriksson, Robert (author)
- Uppsala universitet,Funktionell farmakologi,Institutionen för neurovetenskap
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(creator_code:org_t)
- Elsevier BV, 2008
- 2008
- English.
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In: Biochemical and Biophysical Research Communications - BBRC. - : Elsevier BV. - 0006-291X .- 1090-2104. ; 368:3, s. 476-482
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Recent studies have shown that SNPs in the FTO gene predispose to childhood and adult obesity. In this study, we examined the association between variants in FTO and KIAA1005, a gene that maps closely to FTO, and obesity, as well as obesity related traits among 450 well characterised severely obese children and 512 normal weight controls. FTO showed significant association with several obesity related traits while SNPs in KIAA1005 did not. When stratified by gender, the FTO variant rs9939609 showed association with obesity and BMI among girls (P=0.006 and 0.004, respectively) but not among boys. Gender differences were also found in the associations of the FTO rs9939609 with obesity related traits such as insulin sensitivity and plasma glucose. This study suggests that FTO may have an important role for gender specific development of severe obesity and insulin resistance in children.
Keyword
- FTO
- obesity
- SNP
- diabetes
- children
- body mass index
- insulin
- glucose
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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