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Early Insulin Respo...
Early Insulin Response and Insulin Sensitivity are Equally Important as Predictors of Glucose Tolerance after Correction for Measurement Errors
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- Berglund, Lars, 1955- (author)
- Uppsala universitet,Geriatrik,Uppsala kliniska forskningscentrum (UCR)
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- Berne, Christian (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Endokrin diabetes och metabolism
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- Svärdsudd, Kurt (author)
- Uppsala universitet,Allmänmedicin och klinisk epidemiologi
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- Garmo, Hans (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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- Zethelius, Björn (author)
- Uppsala universitet,Geriatrik
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(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- English.
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In: Diabetes Research and Clinical Practice. - : Elsevier BV. - 0168-8227 .- 1872-8227. ; 86:3, s. 219-224
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Aims: We estimated measurement error (ME) corrected effects of insulin sensitivity (M/I), from euglycaemic insulin clamp, and insulin secretion, measured as early insulin response (EIR) from oral glucose tolerance test (OGTT), on fasting plasma glucose, HbA1c and type 2 diabetes longitudinally and cross-sectional. Methods: : In a population-based study (n = 1128 men) 17 men made replicate measurements to estimate ME at age 71 years. Effect of 1 SD decrease of predictors M/I and EIR on longitudinal response variables fasting plasma glucose (FPG) and HbA1c at follow-ups up to 11 years, were estimated using uncorrected and ME-corrected (with the regression calibration method) regression models. Results: : Uncorrected effect on FPG at age 77 years was larger for M/I than for EIR (effect difference 0.10 mmol/l, 95% CI 0.00;0.21), while ME-corrected effects were similar (0.02 mmol/l, 95% CI -0.13;0.15 mmol/l). EIR had greater ME-corrected impact than M/I on HbA1c at age 82 years (-0.11%, -0.28; -0.01%). Conclusions: : Due to higher ME effect of EIR on glycaemia is underestimated as compared with M/I. By correcting for ME valid estimates of relative contributions of insulin secretion and insulin sensitivity on glycaemia are obtained.
Keyword
- MEDICINE
- MEDICIN
- Geriatrics
- Geriatrik
Publication and Content Type
- ref (subject category)
- art (subject category)
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