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A new approach to e...
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Blessborn, DanielHögskolan Dalarna,Kemiteknik,Dalarna University College, S-781 88 Borlänge, Sweden
(author)
A new approach to evaluate stability of amodiaquine and its metabolite in blood and plasma
- Article/chapterEnglish2006
Publisher, publication year, extent ...
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Elsevier BV,2006
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Numbers
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LIBRIS-ID:oai:dalea.du.se:1619
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https://urn.kb.se/resolve?urn=urn:nbn:se:du-1619URI
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https://doi.org/10.1016/j.jpba.2005.10.018DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-108744URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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A stability study for amodiaquine (AQ) and desethylamodiaquine (AQm) in whole blood and plasma is reported. AQ, AQm and chloroquine (CQ) were simultaneously analysed and the ratios AQ/CQ and AQm/CQ were used to ensure correct interpretation of the stability results. CQ was stable in whole blood and plasma at all tested temperatures enabling it to be a stability marker in stability studies. Simultaneous analysis of compounds, of which at least one is already known to be stable, permits a within sample ratio to be used as a stability indicator, The new approach significantly reduced bias when compared to the traditional approach. AQ and AQm were stable in plasma at -86 degrees C and -20 degrees C for 35 days, at 4 degrees C for 14 days and at 22 degrees C for 1 day. AQ and AQm were stable in blood at -86 degrees C and 4 degrees C for 35 days, at -20 degrees C and 22 degrees C for 7 days and at 37 degrees C for 1 day.
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Neamin, G.Dalarna University College, S-781 88 Borlänge, Sweden
(author)
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Bergqvist, YngveHögskolan Dalarna,Kemiteknik,Dalarna University College, S-781 88 Borlänge, Sweden(Swepub:du)ybq
(author)
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Lindegårdh, N.Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand. Nuffield Department of Clinical Medicine, Centre for Tropical Medicine, University of Oxford, Oxford, UK
(author)
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Högskolan DalarnaKemiteknik
(creator_code:org_t)
Related titles
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In:Journal of Pharmaceutical and Biomedical Analysis: Elsevier BV41:1, s. 207-2120731-70851873-264X
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