Search: onr:"swepub:oai:gup.ub.gu.se/100703" >
A double-blind, ran...
-
Faergemann, Jan,1948Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
(author)
A double-blind, randomized, placebo-controlled, dose-finding study of oral pramiconazole in the treatment of pityriasis versicolor
- Article/chapterEnglish2009
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/100703
-
https://gup.ub.gu.se/publication/100703URI
-
https://doi.org/10.1016/j.jaad.2008.08.033DOI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
BACKGROUND: Pramiconazole is a broad-spectrum triazole antifungal with potential for oral treatment of pityriasis versicolor. OBJECTIVE: We sought to assess the efficacy and tolerability of 5 doses of pramiconazole relative to placebo. METHODS: This was a randomized, multicenter, double-blind, placebo-controlled, 28-day, dose-finding study. A total of 147 patients were randomized to treatment with placebo or one of 5 doses of pramiconazole; treatment lasted for 3 consecutive days. Efficacy was based on mycological response, severity of clinical signs and symptoms, and the Investigator Global Assessment of lesion clearance. RESULTS: A statistically significant (P < .001) dose-dependent effect was observed. When compared with placebo, a significant response (P < .05) was obtained for all but the lowest single dose of pramiconazole. There were no serious, treatment-related adverse events or other safety concerns. LIMITATIONS: The follow-up period was limited to 1 month after treatment onset. CONCLUSIONS: Pramiconazole is a well-tolerated and effective treatment for pityriasis versicolor and the most effective treatment regimen in this study included 200 or 400 mg taken once, and 200 mg taken once daily for 2 or 3 days.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Todd, G.
(author)
-
Pather, S.
(author)
-
Vawda, Z. F.
(author)
-
Gillies, J. D.
(author)
-
Walford, T.
(author)
-
Barranco, C.
(author)
-
Quiring, J. N.
(author)
-
Briones, M.
(author)
-
Göteborgs universitetInstitutionen för kliniska vetenskaper
(creator_code:org_t)
Related titles
-
In:Journal of the American Academy of Dermatology: Elsevier BV61:6, s. 971-9761097-67870190-9622
Internet link
Find in a library
To the university's database
- By the author/editor
-
Faergemann, Jan, ...
-
Todd, G.
-
Pather, S.
-
Vawda, Z. F.
-
Gillies, J. D.
-
Walford, T.
-
show more...
-
Barranco, C.
-
Quiring, J. N.
-
Briones, M.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Dermatology and ...
- Articles in the publication
-
Journal of the A ...
- By the university
-
University of Gothenburg