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Autoantibodies in a...
Autoantibodies in autoimmune polyglandular syndrome type I patients react with major brain neurotransmitter systems.
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Fetissov, Sergueï O (author)
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- Bensing, Sophie (author)
- Karolinska Institutet,Uppsala universitet,Institutionen för medicinska vetenskaper,Autoimmuna sjukdomar (Kämpe)
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- Mulder, Jan (author)
- Karolinska Institutet
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- Le Maitre, Erwan (author)
- Karolinska Institutet
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- Hulting, Anna-Lena (author)
- Karolinska Institutet
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- Harkany, Tibor (author)
- Karolinska Institutet
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- Ekwall, Olov, 1968 (author)
- Uppsala universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Institutionen för medicinska vetenskaper,Autoimmuna sjukdomar (Kämpe)
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- Sköldberg, Filip (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Kolorektalkirurgi,Autoimmuna sjukdomar (Kämpe)
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Husebye, Eystein S (author)
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Perheentupa, Jaakko (author)
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- Rorsman, Fredrik (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Autoimmuna sjukdomar (Kämpe)
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- Kämpe, Olle (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Autoimmuna sjukdomar (Kämpe)
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- Hökfelt, Tomas (author)
- Karolinska Institutet
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(creator_code:org_t)
- Wiley, 2009
- 2009
- English.
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In: The Journal of comparative neurology. - : Wiley. - 1096-9861 .- 0021-9967. ; 513:1, s. 1-20
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https://doi.org/10.1...
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Abstract
Subject headings
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- Patients with autoimmune polyglandular syndrome type I (APS1) often display high titers of autoantibodies (autoAbs) directed against aromatic L-amino acid decarboxylase (AADC), tyrosine hydroxylase (TH), tryptophan hydroxylase (TPH), and glutamic acid decarboxylase (GAD). Neurological symptoms, including stiff-man syndrome and cerebellar ataxia, can occur in subjects with high levels of GAD autoAbs, particularly when patient sera can immunohistochemically stain gamma-aminobutyric acid (GABA) neurons. However, it was not known if APS1 sera can also stain major monoamine systems in the brain. Therefore, in this work we applied sera from 17 APS1 patients known to contain autoAbs against AADC, TH, TPH, and/or GAD to rat brain sections and processed the sections according to the sensitive immunohistochemical tyramide signal amplification method. We found that autoAbs in sera from 11 patients were able to stain AADC-containing dopaminergic, serotonergic, and noradrenergic as well as AADC only (D-group) neurons and fibers in the rat brain, in several cases with a remarkably high quality and sensitivity (dilution up to 1:1,000,000); and, since they are human antibodies, they offer a good opportunity for performing multiple-labeling experiments using antibodies from other species. Six APS1 sera also stained GABAergic neuronal circuitries. Similar results were obtained in the mouse and primate brain. Our data demonstrate that many APS1 sera can immunostain the major monoamine and GABA systems in the brain. Only in a few cases, however, there was evidence that these autoAbs can be associated with neurological manifestations in APS1 patients, as, e.g., shown in previous studies in stiff-man syndrome.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- Animals
- Aromatic-L-Amino-Acid Decarboxylases
- immunology
- Autoantibodies
- blood
- immunology
- Brain
- anatomy & histology
- immunology
- metabolism
- Glutamate Decarboxylase
- genetics
- immunology
- Humans
- Immunohistochemistry
- Male
- Mice
- Mice
- Transgenic
- Neurotransmitter Agents
- immunology
- Polyendocrinopathies
- Autoimmune
- complications
- immunology
- Rats
- Rats
- Sprague-Dawley
- Serum
- immunology
- Stiff-Person Syndrome
- blood
- etiology
- immunology
- Tryptophan Hydroxylase
- immunology
- Tyrosine 3-Monooxygenase
- immunology
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Fetissov, Sergue ...
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Bensing, Sophie
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Mulder, Jan
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Le Maitre, Erwan
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Hulting, Anna-Le ...
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Harkany, Tibor
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show more...
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Ekwall, Olov, 19 ...
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Sköldberg, Filip
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Husebye, Eystein ...
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Perheentupa, Jaa ...
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Rorsman, Fredrik
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Kämpe, Olle
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Hökfelt, Tomas
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Physiology
- Articles in the publication
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The Journal of c ...
- By the university
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University of Gothenburg
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Uppsala University
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Karolinska Institutet