Retrospective study of children with hypophosphatasia with reference to dental changes.

• In the present retrospective study different dental and medical parameters have been analyzed in 17 Swedish children with established hypophosphatasia (HP). It was demonstrated that the basis for the establishment of the diagnosis varied among different dentists and physicians, and that the diagnostic parameters studied among the children varied. The most reliable parameters for HP included raised levels of phosphoethanolamine in urine, and clinical and radiologic findings associated with the legs. These findings were found among the children more often than lowered values of alkaline phosphatase in serum. Histologic analysis of an extracted tooth made a valuable diagnostic complement. It is concluded that a better diagnostic uniformity is recommended. In a well functioning collaboration with well defined tasks, both dentists and physicians can contribute to a reliable diagnosis.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Odontologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Dentistry (hsv//eng)

Keyword

Adolescent

Alkaline Phosphatase

blood

Bone Resorption

pathology

Child

Child

Preschool

Dental Cementum

pathology

Dentin

pathology

Ethanolamines

urine

Female

Humans

Hypophosphatasia

diagnosis

drug therapy

enzymology

genetics

metabolism

pathology

Male

Mandibular Diseases

pathology

Reproducibility of Results

Retrospective Studies

Tooth

pathology

Publication and Content Type

ref (subject category)

art (subject category)