Retrospective study of children with hypophosphatasia with reference to dental changes.

Lundgren, Ted,1959Gothenburg University,Göteborgs universitet,Odontologiska institutionen, Avdelningen för pedodonti,Odontologiska institutionen, Avdelningen för oral biokemi,Institute of Odontology, Department of Pedodontics,Institute of Odontology, Department of Oral Biochemistry (author)

In the present retrospective study different dental and medical parameters have been analyzed in 17 Swedish children with established hypophosphatasia (HP). It was demonstrated that the basis for the establishment of the diagnosis varied among different dentists and physicians, and that the diagnostic parameters studied among the children varied. The most reliable parameters for HP included raised levels of phosphoethanolamine in urine, and clinical and radiologic findings associated with the legs. These findings were found among the children more often than lowered values of alkaline phosphatase in serum. Histologic analysis of an extracted tooth made a valuable diagnostic complement. It is concluded that a better diagnostic uniformity is recommended. In a well functioning collaboration with well defined tasks, both dentists and physicians can contribute to a reliable diagnosis.

Westphal, Otto,1935Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics(Swepub:gu)xwesot (author)
Bolme, P (author)
Modéer, T (author)
Norén, Jörgen G,1947Gothenburg University,Göteborgs universitet,Odontologiska institutionen, Avdelningen för pedodonti,Institute of Odontology, Department of Pedodontics(Swepub:gu)xnorej (author)
Göteborgs universitetOdontologiska institutionen, Avdelningen för pedodonti (creator_code:org_t)

By the author/editor: Lundgren, Ted, 1 ...; Westphal, Otto, ...; Bolme, P; Modéer, T; Norén, Jörgen G, ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dentistry

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