G1 Phase cyclins in cancer development and progression

• Cyclin D1 and cyclin E are rate limiting for progression through G1 and entry into S phase during the cell cycle. Cyclin D1 plays a crucial role in linking favourable environmental conditions with cell cycle progression. Cyclin D1 indirectly induces cyclin E expression and activation which is required for entry into S phase. The deregulated expression of either cyclin would thus greatly impact on a cell’s ability to effectively regulate cell cycle progression. It perhaps not surprising therefore, that both cyclin D1 and cyclin E play important roles in the development and progression of cancer. This chapter explores the roles of these cyclins in cancer. For clarity, the major focus will be on the well characterized roles of cyclin D1 and cyclin E and thus to a lesser extent on other G1 cyclins such as cyclins D2 and D3. This chapter summarizes the evidence linking cyclin D1 and cyclin E to cancer development and progression. The cellular pathways that underlie the deregulated expression of the G1 cyclins in cancer, as well as their oncogenic roles are also discussed. Lastly, this chapter explores the potential of these cyclins to serve as therapeutic targets in cancer therapy.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

NATURVETENSKAP  -- Biologi -- Cellbiologi (hsv//swe)

NATURAL SCIENCES  -- Biological Sciences -- Cell Biology (hsv//eng)

Keyword

Cyclin D

Cyclin E

cell cycle

tumour therapy

Publication and Content Type

vet (subject category)

kap (subject category)