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T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura.
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- Olsson, Bob, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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- Andersson, Per-Ola, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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- Jernås, Margareta, 1961 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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- (creator_code:org_t)
- 2003-08-24
- 2003
- English.
- In: Nature medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 9:9, s. 1123-4
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Chronic idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder that is characterized by increased platelet destruction and is believed to be autoantibody mediated. In this study, CD3+ T cells from ITP patients had increased expression of genes involved in cell-mediated cytotoxicity. In addition, cytotoxic cell-mediated lysis of autologous platelets was shown in active ITP. Our data suggest that T-cell-mediated cytotoxicity is an alternative mechanism for platelet destruction in ITP.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Blood Platelets
- immunology
- physiology
- Case-Control Studies
- Cytotoxicity
- Immunologic
- genetics
- Granzymes
- Humans
- Interferon-gamma
- genetics
- Membrane Glycoproteins
- genetics
- Oligonucleotide Array Sequence Analysis
- Perforin
- Pore Forming Cytotoxic Proteins
- Purpura
- Thrombocytopenic
- Idiopathic
- blood
- genetics
- immunology
- Receptors
- Immunologic
- genetics
- Receptors
- Interleukin-2
- genetics
- Receptors
- KIR
- Serine Endopeptidases
- genetics
- T-Lymphocytes
- Cytotoxic
- immunology
- physiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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