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- Guo, J P (author)
The rat antigen-presenting lectin-like receptor complex influences innate immunity and development of infectious diseases.
- Article/chapterEnglish2009
Publisher, publication year, extent ...
- 2009-03-12
- Springer Science and Business Media LLC,2009
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/105045
- https://gup.ub.gu.se/publication/105045URI
- https://doi.org/10.1038/gene.2009.4DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:118746125URI
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- Language:English
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- SwePubSwePub
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Notes
- Genetic variation in the antigen-presenting lectin-like receptor gene complex (APLEC) associates with autoimmunity and arthritis in rats and humans. We hypothesized that the encoded C-type lectin-like receptors might influence innate immunity and responses to infectious agents. To test this hypothesis, we compared in vivo and in vitro phenotypes in DA rats and APLEC-congenic rats. Survival rates following infection with Staphylococcus aureus and Herpes simplex virus differed significantly between the two strains. Likewise, differential delayed type hypersensitivity (DTH), an immunological reaction involving T lymphocytes and macrophages, was observed in response to provocation with the chemical oxazolone. Unstimulated bone marrow-derived macrophages from the two strains appeared to already have polarized activation states with different mRNA levels of CD163 and Dectin-1 receptors. Following stimulation with a panel of microbial agents, differences in induced mRNA and protein levels were shown for interleukin (IL)-6 and IL-10 following stimulation with lipopolysaccharide, mannan and beta-glucan. Expression levels of APLEC gene mRNAs also differed, and both strains had a notably dichotomous expression of the genes, with general downregulation of all four Dcir genes and upregulation of Mincle and Mcl. We suggest that human APLEC genes may similarly regulate infectious diseases, DTH and general macrophage activation status.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Mikrobiologi inom det medicinska området hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Microbiology in the medical area hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
- Adjuvants
- Immunologic
- pharmacology
- Animals
- Arthritis
- Infectious
- genetics
- immunology
- microbiology
- mortality
- Cells
- Cultured
- Communicable Diseases
- genetics
- immunology
- Cytokines
- biosynthesis
- genetics
- immunology
- Encephalitis
- genetics
- immunology
- virology
- Herpesvirus 1
- Human
- immunology
- Hypersensitivity
- Delayed
- genetics
- immunology
- Immunity
- Innate
- Lectins
- C-Type
- genetics
- immunology
- Lipopolysaccharides
- pharmacology
- Macrophage Activation
- drug effects
- genetics
- immunology
- Macrophages
- immunology
- metabolism
- microbiology
- virology
- Mannans
- pharmacology
- Oxazolone
- pharmacology
- Rats
- Staphylococcal Infections
- genetics
- immunology
- Staphylococcus aureus
- immunology
- Zymosan
- pharmacology
- beta-Glucans
- pharmacology
Added entries (persons, corporate bodies, meetings, titles ...)
- Verdrengh, Margareta,1942Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xverma (author)
- Tarkowski, Andrej,1951Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xtaand (author)
- Lange, Stefan,1948Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xlanst (author)
- Jennische, Eva,1949Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology(Swepub:gu)xjenne (author)
- Lorentzen, J CKarolinska Institutet (author)
- Harris, R AKarolinska Institutet (author)
- Göteborgs universitetInstitutionen för medicin, avdelningen för reumatologi och inflammationsforskning (creator_code:org_t)
Related titles
- In:Genes and immunity: Springer Science and Business Media LLC10:3, s. 227-361476-54701466-4879
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