Helicobacter pylori infection induces interleukin-8 receptor expression in the human gastric epithelium

• The gastric pathogen Helicobacter pylori is known to activate multiple proinflammatory signaling pathways in epithelial cells. In this study, we addressed the question of whether expression of the interleukin-8 receptors IL-8RA (CXCR1) and IL-8RB (CXCR2) is upregulated in H. pylori-infected human gastric biopsy samples. Biopsy samples from patients infected with H. pylori strains harboring the cag pathogenicity island (PAI) expressed larger amounts of both receptors. In addition, IL-8RB expression was induced in the gastric epithelial cell line AGS upon infection with a clinical isolate containing the cag PAI, while a strain lacking the cag PAI did not. Our finding suggests that gastric epithelial cells express IL-8R in response to H. pylori infection.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Microbiology in the medical area (hsv//eng)

Keyword

Adolescent

Adult

Female

Gastric Mucosa/ metabolism

Helicobacter Infections/ immunology

Helicobacter pylori/genetics/pathogenicity

Humans

Male

Middle Aged

Receptors

Interleukin-8A/ biosynthesis

Receptors

Interleukin-8B/ biosynthesis

Up-Regulation

Virulence/genetics

Publication and Content Type

ref (subject category)

art (subject category)