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Helicobacter pylori...
Helicobacter pylori infection induces interleukin-8 receptor expression in the human gastric epithelium
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- Bäckhed, Fredrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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Torstensson, E. (author)
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Seguin, D. (author)
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Richter-Dahlfors, A. (author)
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Rokbi, B. (author)
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(creator_code:org_t)
- 2003
- 2003
- English.
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In: Infect Immun. - 0019-9567. ; 71:6, s. 3357-60
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https://gup.ub.gu.se...
Abstract
Subject headings
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- The gastric pathogen Helicobacter pylori is known to activate multiple proinflammatory signaling pathways in epithelial cells. In this study, we addressed the question of whether expression of the interleukin-8 receptors IL-8RA (CXCR1) and IL-8RB (CXCR2) is upregulated in H. pylori-infected human gastric biopsy samples. Biopsy samples from patients infected with H. pylori strains harboring the cag pathogenicity island (PAI) expressed larger amounts of both receptors. In addition, IL-8RB expression was induced in the gastric epithelial cell line AGS upon infection with a clinical isolate containing the cag PAI, while a strain lacking the cag PAI did not. Our finding suggests that gastric epithelial cells express IL-8R in response to H. pylori infection.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Adolescent
- Adult
- Female
- Gastric Mucosa/ metabolism
- Helicobacter Infections/ immunology
- Helicobacter pylori/genetics/pathogenicity
- Humans
- Male
- Middle Aged
- Receptors
- Interleukin-8A/ biosynthesis
- Receptors
- Interleukin-8B/ biosynthesis
- Up-Regulation
- Virulence/genetics
Publication and Content Type
- ref (subject category)
- art (subject category)
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