Search: onr:"swepub:oai:gup.ub.gu.se/105323" > FOXP3-expressing CD...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 06043naa a2200613 4500 | |
001 | oai:gup.ub.gu.se/105323 | |
003 | SwePub | |
008 | 240528s2009 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/1053232 URI |
024 | 7 | a https://doi.org/10.1111/j.1523-5378.2009.00673.x2 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Kindlund, Bert,d 1969u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology4 aut0 (Swepub:gu)xkinbe |
245 | 1 0 | a FOXP3-expressing CD4(+) T-cell numbers increase in areas of duodenal gastric metaplasia and are associated to CD4(+) T-cell aggregates in the duodenum of Helicobacter pylori-infected duodenal ulcer patients. |
264 | 1 | b Wiley,c 2009 |
520 | a BACKGROUND: We have previously demonstrated that Helicobacter pylori infection is associated with an increased number of CD4(+)CD25(high) regulatory T cells in the gastric and duodenal mucosa. In this study, we determined the number and localization of CD4(+) cells expressing the regulatory T-cell-specific transcription factor FOXP3 in the antrum and duodenum of duodenal ulcer patients, asymptomatic carriers, and uninfected individuals. We also determined gene expression levels of FOXP3 as well as anti- and proinflammatory cytokines before and after H. pylori eradication. METHODS: Cellular FOXP3 expression was studied by immunofluorescence and flow cytometry, and transcription levels of FOXP3, interleukin (IL)-10, transforming growth factor-beta, CD4, and interferon-gamma were analyzed by real-time reverse transcription-polymerase chain reaction. RESULTS: We found an increased (6-fold) frequency of CD4(+)FOXP3(+) T cells in H. pylori-infected gastric mucosa; interestingly 26% of these cells did not co-express CD25. The increase of FOXP3-expressing T cells in the antrum of infected individuals was dependent on the presence of H. pylori, since eradication therapy resulted in 4-fold lower levels of FOXP3 and IL-10 mRNA in the antrum. Furthermore, higher numbers of CD4(+)FOXP3(+) T cells were found in areas of duodenal gastric metaplasia in the duodenum of duodenal ulcer patients compared to duodenal gastric metaplasia of asymptomatic individuals and healthy mucosa in both patient groups. In duodenal ulcer patients, the CD4(+)FOXP3(+) T cells were more highly associated to aggregates in the duodenal mucosa. CONCLUSION: The numbers of CD4(+)FOXP3(+) T cells are increased and localized in CD4(+) T-cell aggregates in areas of duodenal gastric metaplasia in duodenal ulcer patients. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
653 | a CD4-Positive T-Lymphocytes | |
653 | a immunology | |
653 | a Duodenal Ulcer | |
653 | a Flow Cytometry | |
653 | a Forkhead Transcription Factors | |
653 | a Gastric Mucosa | |
653 | a Gene Expression Profiling | |
653 | a Helicobacter Infections | |
653 | a Helicobacter pylori | |
653 | a Interferon-gamma | |
653 | a Interleukin-10 | |
653 | a Intestinal Mucosa | |
653 | a Reverse Transcriptase Polymerase Chain Reaction | |
653 | a T-Lymphocytes | |
653 | a Regulatory | |
653 | a chemistry | |
653 | a immunology | |
653 | a Transforming Growth Factor beta | |
653 | a biosynthesis | |
653 | a Young Adult | |
700 | 1 | a Sjöling, Åsa,d 1968u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology4 aut0 (Swepub:gu)xsjoas |
700 | 1 | a Hansson, Malin,d 1967u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology4 aut0 (Swepub:gu)xhamal |
700 | 1 | a Edebo, Anders,d 1968u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning,Institute of Clinical Sciences, Department of Gastrosurgical Research and Education4 aut0 (Swepub:gu)xedean |
700 | 1 | a Hansson, Lars-Eriku Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery4 aut0 (Swepub:gu)xhanls |
700 | 1 | a Sjövall, Henrik,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine4 aut0 (Swepub:gu)xsjovh |
700 | 1 | a Svennerholm, Ann-Mari,d 1947u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology4 aut0 (Swepub:gu)xsannx |
700 | 1 | a Lundin, Samuel B,d 1970u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology4 aut0 (Swepub:gu)xlusam |
710 | 2 | a Göteborgs universitetb Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi4 org |
773 | 0 | t Helicobacterd : Wileyg 14:3, s. 192-201q 14:3<192-201x 1523-5378x 1083-4389 |
856 | 4 8 | u https://gup.ub.gu.se/publication/105323 |
856 | 4 8 | u https://doi.org/10.1111/j.1523-5378.2009.00673.x |
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