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Relapsing fever Bor...
Relapsing fever Borrelia binds to neolacto glycans and mediates rosetting of human erythrocytes.
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- Guo, Betty P (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Bergström
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- Teneberg, Susann, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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- Münch, Robert (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
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Terunuma, Daiyo (author)
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Hatano, Ken (author)
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Matsuoka, Koji (author)
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- Ångström, Jonas, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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- Borén, Thomas (author)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik
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- Bergström, Sven, 1950- (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Bergström
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(creator_code:org_t)
- 2009-11-17
- 2009
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490 .- 0027-8424. ; 106:46, s. 19280-5
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- A hallmark of acute relapsing fever borreliosis is severe bacteremia. Some Borrelia species, such as B. duttonii and B. crocidurae, associate with erythrocytes and induce aggregation recognized as erythrocyte rosetting. Erythrocyte rosettes contribute to disease severity by increased tissue invasiveness (such as invasion of CNS and encephalitis), hemorrhaging, and reduced blood flow in affected microcapillaries. Here we report that relapsing fever Borrelia binds to neolacto (Galbeta4GlcNAcbeta3Galbeta4Glcbeta1)-carrying glycoconjugates that are present on human erythrocytes. This interaction is of low affinity but is compensated for by the multivalency of neo-lacto-oligosaccharides on the erythrocyte cell surface. Hence, the protein-carbohydrate interaction is dependent on multivalent neolacto-glycans to mediate binding.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Andra medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Other Basic Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Borrelia
- immunology
- Epitopes
- immunology
- Erythrocytes
- immunology
- microbiology
- Globosides
- immunology
- Humans
- Polysaccharides
- immunology
- Relapsing Fever
- immunology
- microbiology
- Rosette Formation
- methods
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Guo, Betty P
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Teneberg, Susann ...
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Münch, Robert
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Terunuma, Daiyo
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Hatano, Ken
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Matsuoka, Koji
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show more...
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Ångström, Jonas, ...
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Borén, Thomas
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Bergström, Sven, ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Other Basic Medi ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
- Articles in the publication
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Proceedings of t ...
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Proceedings of t ...
- By the university
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University of Gothenburg
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Umeå University