Computational screen for spliceosomal RNA genes aids in defining the phylogenetic distribution of the major and minor spliceosomal components

Davila Lopez, Marcela (author): Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology

Alm Rosenblad, Magnus, 1957 (author): Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi,Department of Cell and Molecular Biology

Samuelsson, Tore, 1951 (author): Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology

(creator_code:org_t)

Abstract Subject headings

An essential step of gene expression is the removal of non-coding sequences (introns) from the pre-mRNA and the ligation of coding sequences (exons) to form the mature RNA (mRNA). It is known that the pre-mRNA splicing occurs by two sequential trans-esterification reactions and is catalyzed by a multicomponent complex, the spliceosome. Its assembly involves five small nuclear ribonucleoprotein particles (snRNPs) as well as an array of protein factors, which are determined by the class of intron to be spliced1. To date, two intron classes are known, U2- and U12-type introns. The U2-dependent spliceosome (panel a) is formed by the interaction of the U1, U2, U4/U6 and U5 snRNPs and numerous non-snRNP proteins with the pre-mRNA. The U12-dependent spliceosome (also referred to as the minor spliceosome, panel b), in contrast, consists of the U11, U12, U4atac/U6atac and U5 snRNPs with an unknown number of non-snRNP proteins. Thus, of the main spliceosomal subunits, only the U5 snRNA is common to both spliceosomes2.

By the author/editor: Davila Lopez, Ma ...; Alm Rosenblad, M ...; Samuelsson, Tore ...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Bioinformatics a ...

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Biochemistry and ...

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Cell Biology

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