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A meta-analysis of ...
A meta-analysis of milk intake and fracture risk: low utility for case finding.
- Article/chapterEnglish2005
Publisher, publication year, extent ...
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2004-10-21
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Springer Science and Business Media LLC,2005
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/106053
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https://gup.ub.gu.se/publication/106053URI
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https://doi.org/10.1007/s00198-004-1755-6DOI
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https://research.chalmers.se/publication/106053URI
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https://lup.lub.lu.se/record/895127URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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A low intake of calcium is widely considered to be a risk factor for future fracture. The aim of this study was to quantify this risk on an international basis and to explore the effect of age, gender and bone mineral density (BMD) on this risk. We studied 39,563 men and women (69% female) from six prospectively studied cohorts comprising EVOS/EPOS, CaMos, DOES, the Rotterdam study, the Sheffield study and a cohort from Gothenburg. Cohorts were followed for 152,000 person-years. The effect of calcium intake as judged by the intake of milk on the risk of any fracture, any osteoporotic fracture and hip fracture alone was examined using a Poisson model for each sex from each cohort. Covariates examined were age and BMD. The results of the different studies were merged by using the weighted beta-coefficients. A low intake of calcium (less than 1 glass of milk daily) was not associated with a significantly increased risk of any fracture, osteoporotic fracture or hip fracture. There was no difference in risk ratio between men and women. When both sexes were combined there was a small but non-significant increase in the risk of osteoporotic and of hip fracture. There was also a small increase in the risk of an osteoporotic fracture with age which was significant at the age of 80 years (RR = 1.15; 95% CI = 1.02-1.30) and above. The association was no longer significant after adjustment for BMD. No significant relationship was observed by age for low milk intake and hip fracture risk. We conclude that a self-reported low intake of milk is not associated with any marked increase in fracture risk and that the use of this risk indicator is of little or no value in case-finding strategies.
Subject headings and genre
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Johansson, Helena,1981Gothenburg University,Göteborgs universitet,Institutionen för samhällsmedicin, Avdelningen för geriatrik,Institute of Community Medicine, Dept of Geriatric Medicine,University of Gothenburg(Swepub:gu)xjhell
(author)
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Odén, Anders,1942Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)odena
(author)
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De Laet, Chris
(author)
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Johnell, OlofLund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups(Swepub:lu)orto-ojo
(author)
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Eisman, John A
(author)
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Mc Closkey, Eugene
(author)
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Mellström, Dan,1945Gothenburg University,Göteborgs universitet,Institutionen för samhällsmedicin, Avdelningen för geriatrik,Institute of Community Medicine, Dept of Geriatric Medicine,University of Gothenburg(Swepub:gu)xmelda
(author)
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Pols, Huibert
(author)
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Reeve, Jonathan
(author)
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Silman, Alan
(author)
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Tenenhouse, Alan
(author)
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Göteborgs universitetInstitutionen för samhällsmedicin, Avdelningen för geriatrik
(creator_code:org_t)
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In:Osteoporosis international: Springer Science and Business Media LLC16:7, s. 799-8040937-941X1433-2965
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De Laet, Chris
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Pols, Huibert
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