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A meta-analysis of ...
A meta-analysis of previous fracture and subsequent fracture risk.
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Kanis, J A (author)
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- Johnell, Olof (author)
- Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups
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De Laet, C (author)
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- Johansson, Helena, 1981 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för samhällsmedicin, Avdelningen för geriatrik,Institute of Community Medicine, Dept of Geriatric Medicine,University of Gothenburg
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- Odén, Anders, 1942 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för matematisk statistik,Department of Mathematical Statistics,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg
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Delmas, P (author)
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Eisman, J (author)
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Fujiwara, S (author)
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Garnero, P (author)
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Kroger, H (author)
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McCloskey, E V (author)
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- Mellström, Dan, 1945 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för samhällsmedicin, Avdelningen för geriatrik,Institute of Community Medicine, Dept of Geriatric Medicine,University of Gothenburg
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Melton, L J (author)
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Pols, H (author)
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Reeve, J (author)
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Silman, A (author)
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Tenenhouse, A (author)
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(creator_code:org_t)
- Elsevier BV, 2004
- 2004
- English.
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In: Bone. - : Elsevier BV. - 8756-3282 .- 1873-2763. ; 35:2, s. 375-82
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Abstract
Subject headings
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- Previous fracture is a well-documented risk factor for future fracture. The aim of this study was to quantify this risk on an international basis and to explore the relationship of this risk with age, sex, and bone mineral density (BMD). We studied 15259 men and 44902 women from 11 cohorts comprising EVOS/EPOS, OFELY, CaMos, Rochester, Sheffield, Rotterdam, Kuopio, DOES, Hiroshima, and two cohorts from Gothenburg. Cohorts were followed for a total of 250000 person-years. The effect of a prior history of fracture on the risk of any fracture, any osteoporotic fracture, and hip fracture alone was examined using a Poisson model for each sex from each cohort. Covariates examined were age, sex, and BMD. The results of the different studies were merged by using the weighted beta-coefficients. A previous fracture history was associated with a significantly increased risk of any fracture compared with individuals without a prior fracture (RR = 1.86; 95% CI = 1.75-1.98). The risk ratio was similar for the outcome of osteoporotic fracture or for hip fracture. There was no significant difference in risk ratio between men and women. Risk ratio (RR) was marginally downward adjusted when account was taken of BMD. Low BMD explained a minority of the risk for any fracture (8%) and for hip fracture (22%). The risk ratio was stable with age except in the case of hip fracture outcome where the risk ratio decreased significantly with age. We conclude that previous history of fracture confers an increased risk of fracture of substantial importance beyond that explained by measurement of BMD. Its validation on an international basis permits the use of this risk factor in case finding strategies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Keyword
- Adolescent
- Adult
- Aged
- Aged
- 80 and over
- Bone Density
- Child
- Cohort Studies
- Female
- Fractures
- Bone
- epidemiology
- etiology
- Humans
- Male
- Middle Aged
- Osteoporosis
- epidemiology
- Poisson Distribution
- Risk Assessment
- Female
- prior fracture
- meta-analysis
- osteoporotic fracture
- hip fracture
Publication and Content Type
- ref (subject category)
- art (subject category)
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Bone
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To the university's database
- By the author/editor
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Kanis, J A
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Johnell, Olof
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De Laet, C
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Johansson, Helen ...
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Odén, Anders, 19 ...
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Delmas, P
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show more...
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Eisman, J
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Fujiwara, S
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Garnero, P
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Kroger, H
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McCloskey, E V
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Mellström, Dan, ...
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Melton, L J
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Pols, H
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Reeve, J
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Silman, A
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Tenenhouse, A
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Physiology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Orthopaedics
- Articles in the publication
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Bone
- By the university
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University of Gothenburg
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Chalmers University of Technology
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Lund University