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Genetic variations ...
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Eriksson, Anna-Lena,1971Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
(author)
Genetic variations in sex steroid-related genes as predictors of serum estrogen levels in men.
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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The Endocrine Society,2009
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LIBRIS-ID:oai:gup.ub.gu.se/106228
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https://gup.ub.gu.se/publication/106228URI
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https://doi.org/10.1210/jc.2008-1283DOI
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https://lup.lub.lu.se/record/1404815URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-125046URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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CONTEXT: The risk of many conditions, including prostate cancer, breast cancer, and osteoporosis, is associated with serum levels of sex steroids. OBJECTIVE: The aim of the study was to identify genetic variations in sex steroid-related genes that are associated with serum levels of estradiol (E2) and/or testosterone in men. DESIGN: Genotyping of 604 single nucleotide polymorphisms in 50 sex steroid-related candidate genes was performed in the Gothenburg Osteoporosis and Obesity Determinants (GOOD) study (n = 1041 men; age, 18.9 +/- 0.6 yr). Replications of significant associations were performed in the Osteoporotic Fractures in Men (MrOS) Sweden study (n = 2568 men; age, 75.5 +/- 3.2 yr) and in the MrOS US study (n = 1922 men; age, 73.5 +/- 5.8 yr). Serum E2, testosterone, and estrone (E1) levels were analyzed using gas chromatography/mass spectrometry. RESULTS: The screening in the GOOD cohort identified the single nucleotide polymorphism rs2470152 in intron 1 of the CYP19 gene, which codes for aromatase, responsible for the final step of the biosynthesis of E2 and E1, to be most significantly associated with serum E2 levels (P = 2 x 10(-6)). This association was confirmed both in the MrOS Sweden study (P = 9 x 10(-7)) and in the MrOS US study (P = 1 x 10(-4)). When analyzed in all subjects (n = 5531), rs2470152 was clearly associated with both E2 (P = 2 x 10(-14)) and E1 (P = 8 x 10(-19)) levels. In addition, this polymorphism was modestly associated with lumbar spine BMD (P < 0.01) and prevalent self-reported fractures (P < 0.05). CONCLUSIONS: rs2470152 of the CYP19 gene is clearly associated with serum E2 and E1 levels in men.
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Lorentzon, Mattias,1970Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine(Swepub:gu)xlomat
(author)
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Vandenput, Liesbeth,1974Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine(Swepub:gu)xvanli
(author)
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Labrie, Fernand
(author)
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Lindersson, MarieUppsala universitet,Molekylär medicin
(author)
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Syvänen, Ann-ChristineUppsala universitet,Molekylär medicin(Swepub:uu)anncsyva
(author)
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Orwoll, Eric S
(author)
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Cummings, Steven R
(author)
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Zmuda, Joseph M
(author)
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Ljunggren, ÖstenUppsala universitet,Institutionen för medicinska vetenskaper,Metabola bensjukdomar(Swepub:uu)osteljun
(author)
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Karlsson, MagnusLund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups(Swepub:lu)orto-mka
(author)
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Mellström, Dan,1945Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine(Swepub:gu)xmelda
(author)
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Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine(Swepub:gu)xohlcl
(author)
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Göteborgs universitetInstitutionen för medicin, avdelningen för invärtesmedicin
(creator_code:org_t)
Related titles
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In:The Journal of clinical endocrinology and metabolism: The Endocrine Society94:3, s. 1033-411945-71970021-972X
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Orwoll, Eric S
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