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Liver-derived IGF1 ...
Liver-derived IGF1 enhances the androgenic response in prostate.
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- Svensson, Johan, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine,University of Gothenburg
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- Kindblom, Jon, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,University of Gothenburg
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- Shao, Linus Ruijin, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,University of Gothenburg
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- Movérare-Skrtic, Sofia (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine,University of Gothenburg
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- Lagerquist, Marie (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Rheumatology and Inflammation Research,Institute of Medicine, Department of Internal Medicine
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- Andersson, Niklas, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine,University of Gothenburg
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- Sjögren, Klara, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine,University of Gothenburg
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Venken, Katrien (author)
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Vanderschueren, Dirk (author)
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- Jansson, John-Olov, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,University of Gothenburg
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- Isaksson, Olle, 1943 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine,University of Gothenburg
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine,University of Gothenburg
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- Fick, Jerker (author)
- Göteborgs universitet,University of Gothenburg
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(creator_code:org_t)
- 2008
- 2008
- English.
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In: The Journal of endocrinology. - 1479-6805. ; 199:3, s. 489-97
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Abstract
Subject headings
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- Both IGF1 and androgens are major enhancers of prostate growth and are implicated in the development of prostate hyperplasia and cancer. The aim of the present study was to investigate whether liver-derived endocrine IGF1 modulates the androgenic response in prostate. Mice with adult, liver-specific inactivation of IGF1 (LI-IGF1(-/-) mice) displayed an approximately 80% reduction in serum IGF1 levels associated with decreased prostate weight compared with control mice (anterior prostate lobe -19%, P<0.05; dorsolateral prostate (DLP) lobe -35%, P<0.01; ventral prostate (VP) lobe -47%, P<0.01). Reduced androgen receptor (Ar) mRNA and protein levels were observed in the VP lobe (-34% and -30% respectively, both P<0.05 versus control mice). Analysis of prostate morphology showed reductions in both the glandular and fibromuscular compartments of the VP and DLP lobes that were proportional to the reductions in the weights of these lobes. Immunohistochemistry revealed reduced intracellular AR immunoreactivity in the VP and DLP lobes. The non-aromatizable androgen dihydrotestosterone increased VP weight to a lesser extent in orchidectomized (ORX) LI-IGF1(-/-) mice than in ORX controls (-40%, P<0.05 versus control mice). In conclusion, deficiency of liver-derived IGF1 reduces both the glandular and fibromuscular compartments of the prostate, decreases AR expression in prostate, and reduces the stimulatory effect of androgens on VP weight. These findings may explain, at least in part, the well-known clinical association between serum IGF1 levels and conditions with abnormal prostate growth.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Animals
- Blotting
- Western
- Body Weight
- drug effects
- Dihydrotestosterone
- pharmacology
- Estradiol
- blood
- Immunohistochemistry
- Insulin-Like Growth Factor I
- genetics
- metabolism
- pharmacology
- physiology
- Male
- Mice
- Mice
- Mutant Strains
- Organ Size
- drug effects
- Prostate
- drug effects
- metabolism
- Receptors
- Androgen
- genetics
- metabolism
- Reverse Transcriptase Polymerase Chain Reaction
- Testosterone
- blood
- metabolism
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Svensson, Johan, ...
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Kindblom, Jon, 1 ...
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Shao, Linus Ruij ...
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Movérare-Skrtic, ...
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Lagerquist, Mari ...
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Andersson, Nikla ...
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Sjögren, Klara, ...
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Venken, Katrien
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Vanderschueren, ...
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Jansson, John-Ol ...
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Isaksson, Olle, ...
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Ohlsson, Claes, ...
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Fick, Jerker
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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The Journal of e ...
- By the university
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University of Gothenburg
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Chalmers University of Technology