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Influence of diabet...
Influence of diabetes mellitus on the clinical manifestations and prognosis of infective endocarditis: a report from the International Collaboration on Endocarditis-Merged Database.
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Kourany, Wissam M (author)
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Miro, Jose M (author)
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Moreno, Asuncion (author)
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Corey, G Ralph (author)
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Pappas, Paul A (author)
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Abrutyn, Elias (author)
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Hoen, Bruno (author)
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Habib, Gilbert (author)
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Fowler, Vance G (author)
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Sexton, Daniel J (author)
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- Olaison, Lars, 1949 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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Cabell, Christopher H (author)
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(creator_code:org_t)
- 2009-07-08
- 2006
- English.
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In: Scandinavian journal of infectious diseases. - : Informa UK Limited. - 0036-5548 .- 1651-1980. ; 38:8, s. 613-9
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Abstract
Subject headings
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- The purpose of this investigation was to study the influence of diabetes mellitus (DM) on outcomes of infective endocarditis (IE). Outcomes were compared between 150 diabetic and 905 non-diabetic patients with IE from the International Collaboration on Endocarditis Merged Database. Compared to non-diabetic patients, diabetic patients were older (median age 63 vs 57 y, p<0.001), were more often female (42.0% vs 31.9%, p=0.01), more often had comorbidities (41.5% vs 26.7%, p<0.001), and were more likely to be dialysis dependent (12.7% vs 4.0%, p<0.001). S. aureus was isolated more often (30.7% vs 21.7%, p=0.02), and microorganisms from the viridans Streptococcus group less often (16.7% vs 28.2%, p = 0.001) in the diabetic group. There was no difference with respect to the presence of congestive heart failure, embolism, intra-cardiac abscess, new valvular regurgitation, or valvular vegetation. Diabetic patients underwent surgical intervention less frequently (32.0% vs 44.9%, p = 0.003), and had higher overall in-hospital mortality (30.3% vs 18.6%, p = 0.001). On multivariable analysis, DM was an independent predictor of mortality (odds ratio (OR) = 1.71, 95% confidence interval (CI) 1.08-2.70), especially in male patients, as diabetic males had higher mortality than non-diabetic males (OR 2.18, CI 1.08-4.35). DM is an independent predictor of in-hospital mortality among patients hospitalized with IE.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- Aged
- Diabetes Mellitus
- epidemiology
- microbiology
- Echocardiography
- Endocarditis
- complications
- epidemiology
- Europe
- epidemiology
- Female
- Heart Failure
- epidemiology
- Hospital Mortality
- Humans
- Male
- Middle Aged
- Retrospective Studies
- Staphylococcal Infections
- complications
- epidemiology
- Staphylococcus aureus
- isolation & purification
- United States
- epidemiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kourany, Wissam ...
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Miro, Jose M
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Moreno, Asuncion
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Corey, G Ralph
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Pappas, Paul A
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Abrutyn, Elias
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show more...
-
Hoen, Bruno
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Habib, Gilbert
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Fowler, Vance G
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Sexton, Daniel J
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Olaison, Lars, 1 ...
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Cabell, Christop ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
- Articles in the publication
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Scandinavian jou ...
- By the university
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University of Gothenburg