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Long-term results o...
Long-term results of the international adjuvant lung cancer trial evaluating adjuvant Cisplatin-based chemotherapy in resected lung cancer.
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- Arriagada, Rodrigo (author)
- Karolinska Institutet
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Dunant, Ariane (author)
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Pignon, Jean-Pierre (author)
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- Bergman, Bengt, 1953 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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Chabowski, Mariusz (author)
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Grunenwald, Dominique (author)
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Kozlowski, Miroslaw (author)
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Le Péchoux, Cécile (author)
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Pirker, Robert (author)
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Pinel, Maria-Izabel Sathler (author)
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Tarayre, Michèle (author)
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Le Chevalier, Thierry (author)
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(creator_code:org_t)
- 2010
- 2010
- English.
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In: Journal of clinical oncology. - 1527-7755. ; 28:1, s. 35-42
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Abstract
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- PURPOSE Based on 5-year or shorter-term follow-up data in recent randomized trials, adjuvant cisplatin-based chemotherapy is now generally recommended after complete surgical resection for patients with non-small-cell lung cancer (NSCLC). We evaluated the results of the International Adjuvant Lung Cancer Trial study with three additional years of follow-up. PATIENTS AND METHODS Patients with completely resected NSCLC were randomly assigned to three or four cycles of cisplatin-based chemotherapy or to observation. Cox models were used to evaluate treatment effect according to follow-up duration. Results The trial included 1,867 patients with a median follow-up of 7.5 years. Results showed a beneficial effect of adjuvant chemotherapy on overall survival (hazard ratio [HR], 0.91; 95% CI, 0.81 to 1.02; P = .10) and on disease-free survival (HR, 0.88; 95% CI, 0.78 to 0.98; P = .02). However, there was a significant difference between the results of overall survival before and after 5 years of follow-up (HR, 0.86; 95% CI, 0.76 to 0.97; P = .01 v HR, 1.45; 95% CI, 1.02 to 2.07; P = .04) with P = .006 for interaction. Similar results were observed for disease-free survival. The analysis of non-lung cancer deaths for the whole period showed an HR of 1.34 (95% CI, 0.99 to 1.81; P = .06). CONCLUSION These results confirm the significant efficacy of adjuvant chemotherapy at 5 years. The difference in results beyond 5 years of follow-up underscores the need for the long-term follow-up of other adjuvant lung cancer trials and for a better identification of patients deriving long-term benefit from adjuvant chemotherapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Antineoplastic Combined Chemotherapy Protocols
- therapeutic use
- Carcinoma
- Non-Small-Cell Lung
- drug therapy
- mortality
- Cause of Death
- Cisplatin
- administration & dosage
- Disease-Free Survival
- Female
- Humans
- Lung Neoplasms
- drug therapy
- mortality
- Male
- Middle Aged
Publication and Content Type
- ref (subject category)
- art (subject category)
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Arriagada, Rodri ...
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Dunant, Ariane
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Pignon, Jean-Pie ...
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Bergman, Bengt, ...
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Chabowski, Mariu ...
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Grunenwald, Domi ...
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Kozlowski, Miros ...
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Le Péchoux, Céci ...
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Pirker, Robert
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Pinel, Maria-Iza ...
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Tarayre, Michèle
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Le Chevalier, Th ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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Journal of clini ...
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University of Gothenburg
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Karolinska Institutet