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Functional relevanc...
Functional relevance of the IL-23-IL-17 axis in lungs in vivo.
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- Ivanov, Stefan, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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Bozinovski, Steven (author)
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- Bossios, Apostolos, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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- Valadi, Hadi, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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Vlahos, Ross (author)
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- Malmhäll, Carina, 1959 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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- Sjöstrand, Margareta, 1947 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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Kolls, Jay K (author)
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Anderson, Gary P (author)
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- Lindén, Anders, 1961 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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(creator_code:org_t)
- 2007
- 2007
- English.
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In: American journal of respiratory cell and molecular biology. - 1044-1549. ; 36:4, s. 442-51
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Abstract
Subject headings
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- It is known that interleukin (IL)-23, an IL-12-family cytokine, can be released by certain antigen-presenting cells in response to bacterial pathogens. Recent in vitro studies indicate that this cytokine stimulates a unique subset of CD4 cells, the T helper cell (Th)17 subset, to produce and release the proinflammatory cytokine IL-17. However, it has not been known whether this is an action of IL-23 per se that has bearing for the early innate response in lungs in vivo and whether there is an IL-23-responsive population of IL-17-producing CD4 cells in the bronchoalveolar space. We now present evidence that IL-23 can be involved in the early innate response to both gram-negative and gram-positive bacterial products in the lungs: Recombinant IL-23 protein per se accumulates inflammatory cells in the bronchoalveolar space in part via endogenous production of IL-17, and this IL-17 production occurs locally in IL-23-responsive CD4 cells. This IL-17 response to IL-23 occurs without any pronounced impact on Th1/Th2 polarization. Moreover, recombinant IL-23 protein increases the local MMP-9 activity, which is generated by neutrophils mainly. CD4 cells in the lungs may thus respond to IL-23 from antigen-presenting cells exposed to gram-negative and gram-positive pathogens and thereby reinforce the early innate response. These findings support that IL-23 and IL-17 form a functionally relevant "immunological axis" in the lungs in vivo.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Animals
- Bronchoalveolar Lavage Fluid
- immunology
- Gelatinases
- Immunity
- Innate
- Immunohistochemistry
- Interleukin-17
- metabolism
- Interleukin-23
- metabolism
- pharmacology
- Lipopolysaccharides
- pharmacology
- Lung
- drug effects
- immunology
- metabolism
- Male
- Mice
- Mice
- Inbred BALB C
- Neutrophils
- physiology
- Peptidoglycan
- pharmacology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ivanov, Stefan, ...
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Bozinovski, Stev ...
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Bossios, Apostol ...
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Valadi, Hadi, 19 ...
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Vlahos, Ross
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Malmhäll, Carina ...
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Sjöstrand, Marga ...
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Kolls, Jay K
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Anderson, Gary P
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Lindén, Anders, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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American journal ...
- By the university
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University of Gothenburg