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- Aljassim, ObaidGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine (author)
Inflammatory response and platelet activation after off-pump coronary artery bypass surgery.
- Article/chapterEnglish2006
Publisher, publication year, extent ...
- 2009-07-12
- Informa UK Limited,2006
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/113355
- https://gup.ub.gu.se/publication/113355URI
- https://doi.org/10.1080/14017430500381307DOI
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- Language:English
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- BACKGROUND: Cardiac surgery induces a systemic inflammatory activation and alterations in the hemostatic cascade. The responses contribute to postoperative complications but may also have protective effects. We investigated the relationship between inflammation, hemostasis and bleeding after off-pump coronary artery bypass surgery (OPCAB). METHODS: Ten OPCAB patients were included in a prospective descriptive study. Selected markers of inflammation (IL-6, IL-8, PMN-elastase, C3a, and SC5b-9), and hemostasis (platelet count, ss-thromboglobulin, anti-thrombin, D-dimer and fibrinogen) were measured before and immediately after surgery. Postoperative bleeding was registered. RESULTS: Inflammatory variables did not alter significantly during surgery while ss-thromboglobulin concentrations increased and anti-thrombin and fibrinogen decreased. There were significant postoperative correlations between PMN-elastase and ss-thromboglobulin (r=0.82, p=0.004), between PMN-elastase and fibrinogen (r=0.69, p=0.03) and between C3a and ss-thromboglobulin (r=0.71, p=0.02). In addition, there were significant inverse correlations between postoperative bleeding and pre- and postoperative fibrinogen levels (r=-0.76, p=0.011 and r=-0.84, p=0.002 respectively), between bleeding and postoperative ss-thromboglobulin levels (r=-0.66, p=0.04) and between bleeding and postoperative PMN-elastase (r=-0.75, p=0.01). CONCLUSIONS: The results give further evidence for an association between the inflammatory response and hemostasis after cardiac surgery.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
- Aged
- Complement C3a
- biosynthesis
- Coronary Artery Bypass
- Off-Pump
- Female
- Fibrinogen
- analysis
- Heart Diseases
- blood
- immunology
- surgery
- Hematocrit
- Hemostasis
- Humans
- Leukocyte Elastase
- blood
- Male
- Middle Aged
- Platelet Activation
- Postoperative Hemorrhage
- blood
- immunology
- Postoperative Period
- beta-Thromboglobulin
- biosynthesis
Added entries (persons, corporate bodies, meetings, titles ...)
- Karlsson, Martin,1978Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xkmark (author)
- Wiklund, Lars,1954Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xwikla (author)
- Jeppsson, Anders,1960Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xjepan (author)
- Olsson, Per (author)
- Berglin, Eva,1947Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xbeeva (author)
- Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin (creator_code:org_t)
Related titles
- In:Scandinavian cardiovascular journal : SCJ: Informa UK Limited40:1, s. 43-81401-74311651-2006
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