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Estramustine induce...
Estramustine induces disorganization of microtubules, perinuclear retraction of vimentin and endoplasmatic reticulum, and inhibits cell migration.
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- Rutberg, M (author)
- Gothenburg University,Göteborgs universitet,Zoologiska institutionen,Department of Zoology
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- Wallin, Margareta, 1952 (author)
- Gothenburg University,Göteborgs universitet,Zoologiska institutionen,Department of Zoology
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(creator_code:org_t)
- 1993
- 1993
- English.
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In: Acta histochemica. - 0065-1281. ; 95:2, s. 155-67
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Abstract
Subject headings
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- The effects of the mitotic inhibitor estramustine on the cytoskeleton of DU 145 and AG 1518 cells were studied. Estramustine caused a partial disassembly of microtubules and withdrawal of microtubules from the cell periphery, disorganized microtubules and delayed regrowth of disassembled microtubules. It also induced a spheroid cellular morphology and affected cellular adhesion and survival. Sometimes microtubules seemed to be organized from several microtubule-organizing centers. The cytoskeleton-dependent cell migration was inhibited in the presence of estramustine and the microtubule-interacting vimentin and endoplasmatic reticulum retracted to the perinuclear area. Our results show that not only a complete disassembly of microtubules, but also disturbances of the microtubule network can have dramatic effects on microtubule-dependent processes and localization of cellular organelles. These effects could be of importance in the treatment of prostatic carcinoma with estramustine.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- Cell Adhesion
- drug effects
- Cell Line
- Cell Movement
- drug effects
- Cell Nucleus
- drug effects
- metabolism
- ultrastructure
- Cell Survival
- drug effects
- Endoplasmic Reticulum
- drug effects
- ultrastructure
- Estramustine
- administration & dosage
- pharmacology
- Humans
- Immunohistochemistry
- Microscopy
- Electron
- Scanning
- Microtubules
- drug effects
- ultrastructure
- Vimentin
- immunology
- metabolism
- Vinblastine
- pharmacology
Publication and Content Type
- ref (subject category)
- art (subject category)
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