Mitochondrial targeting of quinones: therapeutic implications.

• Mitochondrial oxidative damage contributes to a range of degenerative diseases. Ubiquinones have been shown to protect mitochondria from oxidative damage, but only a small proportion of externally administered ubiquinone is taken up by mitochondria. Conjugation of the lipophilic triphenylphosphonium cation to a ubiquinone moiety has produced a compound, MitoQ, which accumulates selectively into mitochondria. MitoQ passes easily through all biological membranes and, because of its positive charge, is accumulated several hundred-fold within mitochondria driven by the mitochondrial membrane potential. MitoQ protects mitochondria against oxidative damage in vitro and following oral delivery, and may therefore form the basis for mitochondria-protective therapies.

Subject headings

NATURVETENSKAP  -- Kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Andra medicinska och farmaceutiska grundvetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Other Basic Medicine (hsv//eng)

Keyword

Administration

Oral

Animals

Cations

Cell Membrane

metabolism

Humans

Membrane Potential

Mitochondrial

Membrane Potentials

Mitochondria

metabolism

Mitochondrial Diseases

therapy

Models

Biological

Models

Chemical

Organophosphorus Compounds

metabolism

Oxygen

metabolism

Quinones

chemistry

Ubiquinone

analogs & derivatives

metabolism

Publication and Content Type

ref (subject category)

for (subject category)