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Impact of atrial pr...
Impact of atrial prevention pacing on atrial fibrillation burden: primary results of the Study of Atrial Fibrillation Reduction (SAFARI) trial.
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Gold, Michael R (author)
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Adler, Stuart (author)
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Fauchier, Laurent (author)
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Haffajee, Charles (author)
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Ip, John (author)
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Kainz, Walter (author)
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Kawasaki, Raymond (author)
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Prakash, Atul (author)
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Táborský, Milos (author)
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Waller, Theodore (author)
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Wilson, Vance (author)
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Li, Shelby (author)
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Hoffmann, Ellen (author)
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- Edvardsson, Nils, 1942 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- English.
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In: Heart rhythm : the official journal of the Heart Rhythm Society. - : Elsevier BV. - 1556-3871. ; 6:3, s. 295-301
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: The role of atrial-based pacing algorithms in preventing atrial fibrillation (AF) remains controversial. The inconsistent results noted in previous trials may be due in part to differences in endpoints, pacing algorithms, and study design. SAFARI, a worldwide, prospective, randomized clinical trial, was designed to address these issues and to evaluate the safety and efficacy of a suite of prevention pacing therapies (PPTs) among patients with paroxysmal AF. METHODS AND RESULTS: Patients who met standard pacemaker indications and documented symptomatic AF were implanted with a pacemaker (Vitatron Selection 9000). At 4 months, only patients with documented AF despite dual-chamber pacing were randomized to PPTs ON or PPTs OFF and followed for 6 months. Incidence of permanent AF and change in AF burden were compared between the two groups. Among the 555 patients enrolled, 240 had AF burden at 4 months and were randomized. The risk of developing permanent AF was similar in both groups (0 in the PPTs ON group vs. 3 in the OFF group). However, there was a significant reduction in AF burden between baseline and 10-month follow-up in the ON group compared with the OFF group (median decrease of 0.08 hours/day vs no change, P = .03). CONCLUSION: Among patients with paroxysmal AF and standard bradycardia indications, PPTs are safe and associated with less AF burden compared with conventional pacing.
Keyword
- Aged
- Atrial Fibrillation
- prevention & control
- therapy
- Cardiac Pacing
- Artificial
- adverse effects
- methods
- Female
- Humans
- Male
- Pacemaker
- Artificial
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Gold, Michael R
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Adler, Stuart
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Fauchier, Lauren ...
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Haffajee, Charle ...
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Ip, John
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Kainz, Walter
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show more...
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Kawasaki, Raymon ...
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Prakash, Atul
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Táborský, Milos
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Waller, Theodore
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Wilson, Vance
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Li, Shelby
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Hoffmann, Ellen
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Edvardsson, Nils ...
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show less...
- Articles in the publication
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Heart rhythm : t ...
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Heart Rhythm
- By the university
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University of Gothenburg